P50281

Matrix metalloproteinase-14

UniProtKB/Swiss-Prot protein
Short nameMMP14_HUMAN
Length582 amino acids
SpeciesHomo sapiens (Human)
ProteomeUP000005640
GeneMMP14
Function
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progela...
Family membership
Entry matches to this protein
158250100150200250300350400450500550
200400
HX
Metal binding sites
ZnMc_MMP
Active site
TIMP-binding surface
Peptidase_M10A_matrix
ACT_SITE:
PIRSR
METAL: Zinc; via tele nitrogen; catalytic.
ACT_SITE:
METAL: Calcium 3.
METAL: Zinc 2; via tele nitrogen; catalytic.
METAL: Calcium 4; via carbonyl oxygen.
METAL: Calcium 1; via carbonyl oxygen.
METAL: Zinc 1.
METAL: Zinc 2; via carbonyl oxygen; catalytic.
METAL: Zinc 1; via pros nitrogen.
METAL: Calcium 2.
METAL: Calcium 5; via carbonyl oxygen.
METAL: Calcium 3; via carbonyl oxygen.
METAL: Calcium 2; via carbonyl oxygen.
METAL: Zinc 2; in inhibited form.
METAL: Zinc 1; via tele nitrogen.
MOD_RES: Phosphotyrosine; by PKDCC.
MRMR

InterPro GO terms

Panther GO terms
PTHR10201:SF24
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