P50281
Matrix metalloproteinase-14
UniProtKB/Swiss-Prot protein
Short name | MMP14_HUMAN |
Length | 582 amino acids |
Species | Homo sapiens (Human) |
Proteome | UP000005640 |
Gene | MMP14 |
Function | Endopeptidase that degrades various components of the extracellular matrix such as collagen. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progela... |
Family membership |
Entry matches to this protein
Representative families
Representative domains
Metal binding sites
Active site
TIMP-binding surface
ACT_SITE:
PIRSR
METAL: Zinc; via tele nitrogen; catalytic.
ACT_SITE:
METAL: Calcium 3.
METAL: Zinc 2; via tele nitrogen; catalytic.
METAL: Calcium 4; via carbonyl oxygen.
METAL: Calcium 1; via carbonyl oxygen.
METAL: Zinc 1.
METAL: Zinc 2; via carbonyl oxygen; catalytic.
METAL: Zinc 1; via pros nitrogen.
METAL: Calcium 2.
METAL: Calcium 5; via carbonyl oxygen.
METAL: Calcium 3; via carbonyl oxygen.
METAL: Calcium 2; via carbonyl oxygen.
METAL: Zinc 2; in inhibited form.
METAL: Zinc 1; via tele nitrogen.
MOD_RES: Phosphotyrosine; by PKDCC.
phobius: SIGNAL_PEPTIDE_N_REGION
phobius: SIGNAL_PEPTIDE
phobius: SIGNAL_PEPTIDE_H_REGION
phobius: SIGNAL_PEPTIDE_C_REGION
phobius: NON_CYTOPLASMIC_DOMAIN
phobius: TRANSMEMBRANE
phobius: CYTOPLASMIC_DOMAIN
signalp e: SignalP-noTM
signalp g+: SignalP-TM
tmhmm: TMhelix
InterPro GO terms
biological process
molecular function
cellular component
Panther GO terms
PTHR10201:SF24
biological process
molecular function
cellular component