Q5GIT4
Vascular endothelial growth factor receptor 2
UniProtKB/Swiss-Prot protein
Short name | VGFR2_DANRE |
Length | 1357 amino acids |
Species | Danio rerio (Zebrafish) |
Proteome | UP000000437 |
Gene | kdr |
Function | Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting o... |
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Entry matches to this protein
Feature Display Mode
Summary
Full
Representative families
Representative domains
PIRSR
BINDING: ATP
ACT_SITE: Proton acceptor.
NP_BIND: ATP.
BINDING: ATP.
MOD_RES: Phosphotyrosine; by autocatalysis
NP_BIND: ATP.
BINDING: ATP
METAL: Magnesium; via carbonyl oxygen.
METAL: Magnesium.
NP_BIND: ATP.
phobius: SIGNAL_PEPTIDE_N_REGION
phobius: SIGNAL_PEPTIDE
phobius: SIGNAL_PEPTIDE_H_REGION
phobius: SIGNAL_PEPTIDE_C_REGION
phobius: NON_CYTOPLASMIC_DOMAIN
phobius: TRANSMEMBRANE
phobius: CYTOPLASMIC_DOMAIN
signalp e: SignalP-noTM
tmhmm: TMhelix
InterPro GO terms
biological process
molecular function
cellular component
- None
Panther GO terms
PTHR24416:SF625
biological process
- angiogenesis (GO:0001525)
- cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)
- multicellular organism development (GO:0007275)
- cell migration (GO:0016477)
- positive regulation of cell migration (GO:0030335)
- positive regulation of kinase activity (GO:0033674)
- regulation of MAPK cascade (GO:0043408)
- endothelial cell differentiation (GO:0045446)
- positive regulation of angiogenesis (GO:0045766)
molecular function
cellular component