A0A011PFG4

Methionine synthase

UniProtKB/TrEMBL protein
Short nameA0A011PFG4_9PROT
Length1235 amino acids
SpeciesCandidatus Accumulibacter sp. SK-11
ProteomeUP000020226
GenemetH
Function
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
112351002003004005006007008009001,0001,1001,200
5001000
B12_B…B12_BINDI…ADOMET_ACTIVATIONPTERIN_BINDINGHCY
Representative domains
MeTr
Substrate binding pocket
methionine_synthas…
B12 binding site
Cobalt ligand
MetH
BINDING: Methylcob(III)alamin.
REGION: Methylcob(III)alamin binding.
BINDING: Methylcob(III)alamin; via amide nitrogen.
REGION: S-adenosyl-L-methionine binding.
BINDING: S-adenosyl-L-methionine.
BINDING: S-adenosyl-L-methionine; via carbonyl oxygen.
BINDING: methylcob(III)alamin / Co; axial binding residue.
BINDING: Zn(2+).
PIRSR
METAL: Zinc.

InterPro GO terms

Panther GO terms
PTHR45833:SF1
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