UP000001473

Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)

UniProtKB proteome
Proteome ID
UP000001473
StrainDSM 44385
TaxonomyCorynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)

Description

Bacteria from the genus Corynebacterium are Gram-positive, nonmotile rods which include both pathogenic and non-pathogenic species that can live in a large variety of habitats. In addition to being animal and human pathogens, they have been isolated from soil, plant material, waste water, and dairy products. Corynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717) is a Gram-positive bacterium isolated from sputum of an 82-year-old female with pulmonary disease. C.kroppenstedtii is phenotypically readily distinguished from most other corynebacteria in lacking the so-called (coryno)mycolic acids, alpha-alkyl-beta-hydroxy long-chain fatty acids with approximately 22-35 carbon atoms that are important structural components of the corynebacterial cell envelope. It is characterized by its lipophilic (lipid-requiring) phenotype and is unable to grow on synthetic media lacking lipid supplementation. It possesses a large repertoire of genes involved in sugar uptake and central carbohydrate metabolism and the presence of the mevalonate route for isoprenoid biosynthesis. The lack of mycolic acids and the lipophilic lifestyle of C. kroppenstedtii are apparently caused by gene loss, including a condensase gene cluster, a mycolate reductase gene, and a microbial type I fatty acid synthase gene. A complete oxidation pathway involved in the degradation of fatty acids is present in the genome. Evaluation of the genomic data indicated that lipophilism is the dominant feature involved in pathogenicity of C. kroppenstedtii. C.kroppenstedtii is rarely recognized in human clinical samples, but it is recovered from respiratory specimens as well as from breast tissue, pus or deep wound swaps of patients with mastitis. Pathological data reveals an association between infection by C. kroppenstedtii and inflammatory breast disease. The pathogenicity of C. kroppenstedtii might be associated with its ability to colonize fat globules, in which the organism can apparently multiply irrespective of the neutrophil response. (Adaptated from PMID: 18430482).

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