UP000008205

Escherichia coli O127:H6 (strain E2348/69 / EPEC)

UniProtKB proteome
Proteome ID
UP000008205
StrainE2348/69 / EPEC
TaxonomyEscherichia coli O127:H6 (strain E2348/69 / EPEC)

Description

Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesising appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material. Strain E2348/69, a phylogroup B2 strain, was isolated in Taunton, England in 1969 and is widely used as a model for EPEC (enteropathogenic Ecoli) strains. It is the first EPEC strain to be fully sequenced. EPEC strains are a leading cause of infantile diarrhea in developing countries. EPEC infections are characterized by attaching and effacing lesions which are characterized by microvilli destruction, intimate adherence of bacteria to the intestinal epithelium, pedestal formation, and aggregation of polarized actin and other elements of the cytoskeleton at sites of bacterial attachment. They do not invade cells or release diffusible toxins. This strain is probably capable of utilizing propanediol as a carbon source.

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