cl15354

CBS_pair_SF

CDD set
Accession
cl15354
Member databaseCDD
External Links

Description

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily. CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.
4.27e-234.23e-201.95e-185.4e-172.5e-163.23e-165.38e-165.62e-166.95e-161.41e-152.49e-152.36e-154.16e-158.91e-142.26e-131.53e-132.48e-133.2e-134.75e-136.28e-131.15e-123.19e-125.31e-125.31e-126.74e-121.48e-111.48e-111.48e-112.68e-111.14e-103.16e-104.09e-104.09e-104.09e-106.81e-102.44e-93.15e-94.07e-94.22e-95.26e-98.76e-91.14e-83.14e-81.46e-74.04e-76.74e-73.12e-64.03e-63.64e-61.45e-52.41e-52.79e-51.12e-41.44e-44e-48.62e-48.62e-48.62e-41.92e-132.13e-71.66e-61.66e-64.42e-54.47e-49.23e-81.54e-72e-75.58e-77.22e-79.34e-71.56e-61.56e-62.81e-65.65e-65.01e-67.3e-67.3e-61.58e-51.58e-52.04e-53.42e-53.53e-57.39e-59.55e-59.55e-51.6e-41.52e-41.6e-41.6e-41.76e-42.67e-42.67e-43.45e-43.45e-43.45e-45.78e-42.22e-191.16e-176.45e-174.17e-164.39e-151.93e-154.34e-155.07e-151.64e-144.26e-143.02e-132.72e-121.76e-124.43e-123.45e-122.52e-111.46e-118.08e-122.63e-112.26e-119.46e-115.18e-101.32e-95.95e-102.19e-97.44e-92.31e-81.05e-74.99e-78.35e-79.34e-72.82e-63.61e-62.28e-65.2e-61.59e-51.09e-53.28e-55.72e-53.74e-59.03e-51.64e-45.07e-43.92e-46.99e-43.64e-41.01e-174.59e-156.93e-153.53e-142.05e-134.52e-131.62e-123.16e-128.85e-121.36e-111.9e-114.12e-117.4e-114.41e-109.48e-101.22e-92.63e-99.4e-99.4e-99.4e-91.05e-81.21e-81.02e-82.02e-84.34e-85.6e-85.6e-85.6e-89.32e-89.23e-81.2e-71.55e-73.34e-72.42e-74.3e-73.87e-61.18e-51.97e-57.05e-57.05e-51.95e-45.64e-95.73e-131.28e-183.21e-167.18e-158.91e-144.82e-132.52e-135.91e-138.22e-131.46e-126.84e-126.74e-121.14e-111.78e-101.48e-97.91e-101.96e-91.76e-91.67e-91.01e-81.8e-81.09e-81.68e-82.07e-71.19e-71.04e-62.92e-64.19e-62.78e-61.99e-68.67e-68.2e-61.89e-51.61e-51.89e-51.41e-53.13e-57.32e-53.74e-57.71e-57.68e-51.88e-42.51e-46.36e-46.49e-46.8e-48.64e-49.39e-163.39e-152.39e-147.4e-131.24e-122.03e-125.77e-122.08e-113.47e-115.34e-112.09e-102.7e-104.52e-109.03e-101.26e-93.52e-99.82e-92.74e-89.88e-81.28e-71.87e-75.95e-77.69e-79.94e-71.66e-62.03e-63.59e-65.99e-66.49e-67.74e-61e-51.29e-51.29e-52.16e-52.79e-54.66e-51.01e-48.58e-52.17e-42.17e-42.81e-43.63e-43.63e-46.07e-43.16e-101.13e-81.89e-86.74e-71.87e-62.42e-63.12e-64.03e-64.02e-55.19e-57.39e-58.21e-51.12e-43.1e-47.39e-59.02e-41.54e-52.82e-56.68e-51.3e-42.05e-41.74e-198.43e-164.8e-151.84e-144.03e-132.44e-121.14e-112.47e-118.93e-111.15e-101.93e-102.3e-101.67e-93.3e-84.27e-87.14e-81.19e-72e-74.32e-74.9e-77.22e-72.61e-62.61e-62.61e-63.38e-65.65e-67.3e-61.58e-52.04e-57.39e-59.55e-51.6e-42.17e-43.45e-45.78e-47.7e-71.29e-63.64e-63.74e-56.27e-52.29e-43.84e-44.97e-41.43e-94.29e-71.21e-61.57e-63.53e-54.57e-54.57e-52.81e-43.64e-44.72e-44.72e-46.12e-41.57e-123.55e-102.16e-91.35e-73.79e-74.9e-72.31e-63.87e-63.87e-66.49e-66.49e-61.33e-51.41e-51.82e-51.82e-51.82e-52.36e-53.05e-53.95e-53.95e-53.95e-53.95e-51.11e-41.44e-41.86e-42.41e-42.41e-48.76e-48.76e-43.81e-52.4e-49.88e-46.74e-121.9e-113.18e-118.96e-111.16e-101.95e-107.11e-107.3e-91.22e-81.22e-81.59e-83.45e-83.45e-82.11e-72.73e-73.54e-73.54e-74.59e-71.29e-61.67e-64.84e-56.27e-51.05e-41.36e-41.36e-42.96e-43.84e-48.34e-41.91e-115.4e-101.29e-92.55e-83.3e-83.3e-89.23e-85.58e-71.56e-62.46e-63.38e-63.38e-63.38e-64.37e-67.3e-61.22e-51.22e-52.04e-52.64e-53.42e-54.42e-55.71e-59.55e-52.67e-42.67e-44.47e-45.78e-47.47e-42.86e-108.51e-108.79e-101.41e-93.03e-98.85e-99.53e-91.85e-88.95e-92.12e-81.09e-86.33e-88.04e-82.59e-73.06e-73.8e-74.86e-78.7e-71.47e-62.11e-61.2e-52.32e-54.45e-54.45e-54.23e-51.3e-41.3e-41.11e-45.07e-43.92e-43.41e-46.8e-48.38e-41.2e-144.86e-141.49e-138.12e-122.78e-103.32e-104.48e-91.36e-82.98e-84.9e-82.43e-82.79e-85.97e-71.62e-62.08e-61.47e-64.78e-65.93e-69.34e-61.02e-51.98e-52.09e-52.43e-56.9e-51.14e-41.14e-49.57e-52.41e-43.09e-45.76e-47.1e-48.76e-49.02e-41.52e-131.35e-116.72e-113.08e-103.03e-91.13e-86.38e-86.21e-81.13e-76.27e-78.08e-75.24e-71.04e-61.34e-62.87e-64.78e-64.91e-61.02e-52.28e-54.69e-54.69e-54.46e-56.05e-51.3e-41.3e-42.15e-41.95e-41.35e-134.88e-101.36e-88.17e-81.06e-71.06e-71.36e-72.95e-54.92e-54.92e-51.06e-41.37e-41.37e-44.93e-44.04e-44.9e-83.59e-83.71e-82.93e-71.45e-61.45e-64.78e-65.05e-63.23e-59.92e-59.92e-52.59e-43.49e-45.95e-49.44e-46.33e-81.06e-75.93e-65.01e-62.09e-51.7e-53.13e-51.17e-41.57e-41.86e-42.26e-43.41e-49.14e-47.32e-49.14e-41.6e-111.6e-119.76e-111.64e-102.12e-102.16e-92.8e-92.21e-81.78e-63.87e-61.09e-51.09e-52.36e-52.36e-53.95e-56.63e-51.11e-41.11e-41.44e-44.04e-46.77e-48.76e-48.76e-43.15e-92.27e-77.94e-69.31e-61.12e-54.1e-48.51e-108.95e-92.04e-82.16e-81.46e-71.1e-61.04e-63.49e-55.75e-52.52e-43.58e-42.54e-43.97e-101.06e-71.13e-74.03e-57.42e-59.57e-57e-53.23e-45.68e-41.88e-172.43e-175.4e-171.05e-112.25e-114.82e-111.14e-102.98e-107.91e-101.36e-91.68e-82.16e-83.36e-85.98e-89.94e-82.13e-72.75e-74.58e-71.61e-52.08e-55.75e-51.23e-42.65e-44.04e-46.13e-102.79e-81.59e-118.51e-101.82e-91.21e-72.56e-71.63e-62.49e-68.67e-69.88e-41.23e-42.43e-62.87e-61.22e-51.02e-54.02e-53.09e-43.1e-45.52e-48.73e-43.25e-184.17e-163.76e-138.88e-136.86e-121.14e-111.9e-102.3e-104.09e-104.09e-108.76e-98.76e-91.46e-82.43e-84.06e-85.24e-81.46e-71.88e-72.43e-73.13e-71.12e-62.41e-54.19e-132.26e-124.04e-111.47e-106.6e-104.98e-101.82e-93.9e-92.27e-72.75e-73.77e-75.75e-56.05e-51.01e-41.01e-43.58e-44.61e-44.2e-49.88e-49.88e-41.08e-81.84e-83.14e-82e-75.9e-75.05e-61.26e-54.46e-57.36e-59.47e-55.05e-43.18e-111.44e-231.9e-177.32e-126.84e-122.93e-114.13e-103.64e-91.31e-84.89e-92.27e-75.16e-72.61e-54.46e-58.98e-51.15e-41.14e-106.81e-104.07e-98.17e-88.7e-71.12e-64.03e-66.72e-61.45e-54.02e-52.4e-41.78e-102.34e-95.15e-82.42e-76.77e-73.18e-62.5e-52.5e-54.18e-51.52e-47.11e-41.87e-53.64e-51.17e-44.02e-52.54e-41.49e-105.18e-103.18e-86.27e-71.78e-51.26e-53.81e-52.13e-41.95e-42.78e-43.92e-49.44e-42.36e-63.3e-71.59e-53.81e-53.96e-46.49e-49.88e-47.91e-101.02e-98.36e-91.39e-81.79e-82.98e-84.78e-66.16e-61.7e-59.1e-53.81e-44.61e-49.88e-46.07e-45.23e-41.24e-163.93e-154.19e-135.4e-136.84e-124.88e-116.72e-111.03e-101.1e-91.41e-95.64e-91.02e-53.64e-59.88e-46.21e-113.55e-72.72e-62.72e-65.83e-61.06e-52.68e-59.57e-54.4e-49.02e-46.33e-81.37e-62.28e-64.91e-68.2e-63.81e-54.58e-73.63e-145.76e-123.39e-91.87e-75.05e-65.05e-68.38e-64.94e-55.83e-62.68e-57.05e-54.72e-42.65e-44.67e-145.33e-64.23e-53.92e-48.64e-41.28e-147.62e-66.75e-46.51e-41.29e-111.73e-181.04e-54.03e-57.36e-53.9e-41.62e-57.03e-52.59e-41.29e-41.61e-183.3e-77.11e-61.84e-44.27e-63.13e-51.84e-43.34e-42.54e-5CBS_pair_SF - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamilyCBS_pair_voltage-gated_CLC_euk_bac - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteriaCBS_pair_voltage-gated_CLC_archaea - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in archaeaCBS_pair_DHH_polyA_Pol_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the DHH and nucleotidyltransferase (NT) domainsCBS_pair_DRTGG_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the DRTGG domainCBS_pair_inorgPPase - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with family II inorganic pyrophosphataseCBS_pair_GGDEF_EAL - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the GGDEF (DiGuanylate-Cyclase (DGC)) domainCBS_pair_GGDEF_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the GGDEF (DiGuanylate-Cyclase (DGC)) domainCBS_pair_HPP_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domainCBS_pair_arch2_repeat1 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in archaea, repeat 1CBS_pair_peptidase_M50 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in the metalloprotease peptidase M50CBS_pair_proteobact - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in proteobacteriaCBS_euAMPK_gamma-like_repeat2 - CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinaseCBS_pair_bac - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteriaCBS_pair_KefB_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the KefB (Kef-type K+ transport systems) domainCBS_pair_SIS_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the with the SIS (Sugar ISomerase) domainCBS_pair_arch_MET2_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the MET2 domainCBS_pair_Mg_transporter - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the magnesium transporter, MgtECBS_pair_NTP_transferase_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domainCBS_pair_CBS - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domainCBS_pair_ParBc_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a ParBc (ParB-like nuclease) domainCBS_pair_voltage-gated_CLC_bac - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in bacteriaCBS_pair_ABC_OpuCA_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found associated with the ABC transporter OpuCACBS_pair_arch2_repeat2 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in archaea, repeat 2CBS_pair_GGDEF_PAS_repeat2 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in diguanylate cyclase/phosphodiesterase proteins with PAS sensors, repeat 2CBS_pair_CcpN - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains of CcpN repressorCBS_euAMPK_gamma-like_repeat1 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1CBS_two-component_sensor_histidine_kinase_repeat1 - 2 tandem repeats of the CBS domain in the two-component sensor histidine kinase and related-proteins, repeat 1CBS_pair_HRP1_like - CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteindsCBS_pair_bac_euk - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria and eukaryotesCBS_pair_peptidase_M50 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in the metalloprotease peptidase M50CBS_pair_ABC_OpuCA_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found associated with the ABC transporter OpuCACBS_pair_AcuB_like - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ACT domainCBS_pair_IMPDH - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) proteinCBS_pair_CAP-ED_NT_Pol-beta-like_DUF294_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors, the NT (Nucleotidyltransferase) Pol-beta-like domain, and the DUF294 domainCBS_pair_CAP-ED_NT_Pol-beta-like_DUF294_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors, the NT (Nucleotidyltransferase) Pol-beta-like domain, and the DUF294 domainCBS_pair_voltage-gated_CLC_euk_bac - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteriaCBS_pair_BON_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domainCBS_pair_archHTH_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in archaea and associated with helix turn helix domainCBS_pair_bac - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteriaCBS_pair_bac - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteriaCBS_archAMPK_gamma-repeat2 - CBS pair domains found in archeal 5'-AMP-activated protein kinase gamma subunit-like proteinsCBS_pair_arch1_repeat2 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in archaea, repeat 2CBS_pair_CorC_HlyC_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domainCBS_pair_arch1_repeat1 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in archaea, repeat 1CBS_arch_repeat1 - CBS pair domains found in archeal proteins, repeat 1CBS_pair_bac_arch - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria and archaeaCBS_pair_Euryarchaeota - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in EuryarchaeotaCBS_archAMPK_gamma-repeat1 - signal transduction protein with CBS domainsCBS_pair_CAP-ED_NT_Pol-beta-like_DUF294_assoc - CBS domain proteinCBS_two-component_sensor_histidine_kinase_repeat2 - 2 tandem repeats of the CBS domain in the two-component sensor histidine kinase and related-proteins, repeat 2CBS_pair_bac - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteriaCBS_pair_MUG70_2 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains similar to MUG70 repeat2CBS_pair_Thermoplasmatales - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in ThermoplasmatalesCBS_pair_NeuB - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domain present in N-acylneuraminate-9-phosphate synthaseCBS_pair_bact_arch - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria and archaeaCBS_pair_DHH_polyA_Pol_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the DHH and nucleotidyltransferase (NT) domainsCBS_pair_ABC_Gly_Pro_assoc - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found associated with the glycine betaine/L-proline ABC transporterCBS_pair_arch - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in archaeaCBS_pair_bac - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteriaCBS_arch_repeat2 - CBS pair domains found in archeal proteins, repeat 2CBS_pair_GGDEF_PAS_repeat1 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in diguanylate cyclase/phosphodiesterase proteins with PAS sensors, repeat 1CBS_pair_MUG70_1 - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains similar to MUG70 repeat1CBS_pair_ACT - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in Thermatoga in combination with an ACT domainCBS_pair_bac - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteriaCBS_pair_plant_CBSX - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains from plant CBSX proteinsCBS_pair_arch - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domainsCBS_pair_chlorobiales - Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in chlorobiales
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