CL0053

4H_Cytokine

Pfam clan
Accession
CL0053
Member databasePfam
AuthorsBateman A

Description

Cytokines are regulatory peptides that can be produced by various cells for communicating and orchestrating the large multicellular system. Cytokines are key mediators of hematopoiesis, immunity, allergy, inflammation, tissue remodeling, angiogenesis, and embryonic development [2]. This superfamily includes both the long and short chain helical cytokines.

References

1. Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes. Hill EE, Morea V, Chothia C J Mol Biol 322, 205-233, (2002). PMID: 12215425

2. Phylogeny of a growth hormone-like cytokine superfamily based upon 3D structure. Ouyang S, He F J Mol Evol 56, 131-136, (2003). PMID: 12574859

1e-53.6e-44.3e-42.6e-78.1e-41.1e-8LIF_OSM - LIF / OSM familyPRF - Plethodontid receptivity factor PRFIL6 - Interleukin-6/G-CSF/MGF familyIL3 - Interleukin-3Leptin - LeptinIL13 - Interleukin-13IFN-gamma - Interferon gammaIL2 - Interleukin 2IL10 - Interleukin 10GM_CSF - Granulocyte-macrophage colony-stimulating factorInterferon - Interferon alpha/beta domainCSF-1 - Macrophage colony stimulating factor-1 (CSF-1)IL7 - Interleukin 7CNTF - Ciliary neurotrophic factorSCF - Stem cell factorIL11 - Interleukin 11IL12 - Interleukin-12 alpha subunitIL15 - Interleukin 15IL4 - Interleukin 4IL5 - Interleukin 5Flt3_lig - flt3 ligandEPO_TPO - Erythropoietin/thrombopoietinHormone_1 - Somatotropin hormone familyIL23 - Interleukin 23 subunit alphaGCSF - Granulocyte colony-stimulating factorIL34 - Interleukin 34IL28A - Interleukin-28AIL22 - Interleukin 22 IL-10-related T-cell-derived-inducible factorTSLP - Thymic stromal lymphopoietin
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