CL0053
4H_Cytokine
Pfam clan
Accession | CL0053 |
Member database | Pfam |
Authors | Bateman A |
Description
Cytokines are regulatory peptides that can be produced by various cells for communicating and orchestrating the large multicellular system. Cytokines are key mediators of hematopoiesis, immunity, allergy, inflammation, tissue remodeling, angiogenesis, and embryonic development [2]. This superfamily includes both the long and short chain helical cytokines.
References
1. Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes. Hill EE, Morea V, Chothia C J Mol Biol 322, 205-233, (2002). PMID: 12215425
2. Phylogeny of a growth hormone-like cytokine superfamily based upon 3D structure. Ouyang S, He F J Mol Evol 56, 131-136, (2003). PMID: 12574859
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