CL0071

His_phosphatase

Pfam clan
Accession
CL0071
Member databasePfam
AuthorsFinn RD, Rigden DJ

Description

The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches [1].

References

1. The histidine phosphatase superfamily: structure and function. Rigden DJ Biochem J. 409, 333-348, (2008). PMID: 18092946

His_Phos_2 - Histidine phosphatase superfamily (branch 2)His_Phos_1 - Histidine phosphatase superfamily (branch 1)
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