CL0286

GCS

Pfam clan
Accession
CL0286
Member databasePfam
AuthorsBateman A, Pei J

Description

This clan represents a superfamily of carboxylate-amine/ammonia ligases [1] that includes Gamma-Glutamylcysteine synthetase (gamma-GCS) and glutamine synthetase (GS). Gamma-Glutamylcysteine synthetase (gamma-GCS) catalyses the first step in the de novo biosynthesis of glutathione.

References

1. Structure prediction and active site analysis of the metal binding determinants in gamma -glutamylcysteine synthetase. Abbott JJ, Pei J, Ford JL, Qi Y, Grishin VN, Pitcher LA, Phillips MA, Grishin NV J Biol Chem. 276, 42099-42107, (2001). PMID: 11527962

5.2e-3Amidoligase_2 - Putative amidoligase enzymeGatB_N - GatB/GatE catalytic domainGCS - Glutamate-cysteine ligaseATP-gua_Ptrans - ATP:guanido phosphotransferase, C-terminal catalytic domainGCS2 - Glutamate-cysteine ligase family 2(GCS2)Pup_ligase - Pup-ligase proteinGln-synt_C - Glutamine synthetase, catalytic domainGlu_cys_ligase - Glutamate-cysteine ligaseDUF2126 - Putative amidoligase enzyme (DUF2126)Hyphal_reg_CWP - Hyphally regulated cell wall protein N-terminal
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