CL0286
GCS
Pfam clan
Accession | CL0286 |
Member database | Pfam |
Authors | Bateman A, Pei J |
Description
This clan represents a superfamily of carboxylate-amine/ammonia ligases [1] that includes Gamma-Glutamylcysteine synthetase (gamma-GCS) and glutamine synthetase (GS). Gamma-Glutamylcysteine synthetase (gamma-GCS) catalyses the first step in the de novo biosynthesis of glutathione.
References
1. Structure prediction and active site analysis of the metal binding determinants in gamma -glutamylcysteine synthetase. Abbott JJ, Pei J, Ford JL, Qi Y, Grishin VN, Pitcher LA, Phillips MA, Grishin NV J Biol Chem. 276, 42099-42107, (2001). PMID: 11527962
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