CL0572

TIKI

Pfam clan
Accession
CL0572
Member databasePfam
AuthorsCoggill P

Description

TIKI superfamily proteins carry a core fold contributing to the enzymic activity, that ranges from metalloprotease, erythromycin esterase and bacterial toinosis as in the MARTX and dermonecrotic toxin families, amongst others. All superfamily members carry the active site residues of two histidines and two glutamates [1]. Tiki proteins themselves antagonize Wnt activity upstream of its receptor.

References

1. Tiki, at the head of a new superfamily of enzymes. Sanchez-Pulido L, Ponting CP Bioinformatics. 29, 2371-2374, (2013). PMID: 23868957

4.1e-44.5e-3Cofac_haem_bdg - Haem-binding uptake, Tiki superfamily, ChaNErythro_esteras - Erythromycin esteraseTraB_PrgY_gumN - TraB/PrgY/gumN familyHopBA1 - Type III effector protein HopBA1
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