CL0572
TIKI
Pfam clan
Accession | CL0572 |
Member database | Pfam |
Authors | Coggill P |
Description
TIKI superfamily proteins carry a core fold contributing to the enzymic activity, that ranges from metalloprotease, erythromycin esterase and bacterial toinosis as in the MARTX and dermonecrotic toxin families, amongst others. All superfamily members carry the active site residues of two histidines and two glutamates [1]. Tiki proteins themselves antagonize Wnt activity upstream of its receptor.
References
1. Tiki, at the head of a new superfamily of enzymes. Sanchez-Pulido L, Ponting CP Bioinformatics. 29, 2371-2374, (2013). PMID: 23868957
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