CL0724

Kinetochore

Pfam clan
Accession
CL0724
Member databasePfam
AuthorsBateman A

Description

In mitosis, chromosomes replicate and the resulting sister-chromatid pairs are held together along their length by cohesin complexes. Associated with the centromere of each chromatid is a kinetochore, a specialized protein assembly that captures microtubules (MTs) of the mitotic spindle. This superfamily includes a range of kinetochore proteins such as Csm1, Spc24 and Spc25 [1].

References

1. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC Cell. 142, 556-567, (2010). PMID: 20723757

2. Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. Sironi L, Mapelli M, Knapp S, De Antoni A, Jeang KT, Musacchio A EMBO J. 21, 2496-2506, (2002). PMID: 12006501

Spc24 - Spc24 subunit of Ndc80MAD - Mitotic checkpoint proteinCENP-O - Cenp-O kinetochore centromere componentSpindle_Spc25 - Chromosome segregation protein Spc25Csm1 - Chromosome segregation protein Csm1/Pcs1
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