1ca0

BOVINE CHYMOTRYPSIN COMPLEXED TO APPI

PDB structure
Accession
1ca0
Experiment typeX-ray
Resolution2.1 Å
ChainsA, B, C, D, F, G, H, I
Released23 July 1997

Chain B ( P00766)

Domains in the chain

Chain C ( P00766)

Domains in the chain
197102030405060708090
50ANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN
PDB: Chain C
Peptidase_S1
Representative families
Peptidase_S1

Chain G ( P00766)

Domains in the chain

Chain H ( P00766)

Domains in the chain
197102030405060708090
50ANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN
PDB: Chain H
Peptidase_S1
Representative families
Peptidase_S1

References

1. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Scheidig, A.J., Hynes, T.R., Pelletier, L.A., Wells, J.A., Kossiakoff, A.A. Protein Sci. 6, 1806-1824, (1997). View articlePMID: 9300481

2. X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor. Hynes, T.R., Randal, M., Kennedy, L.A., Eigenbrot, C., Kossiakoff, A.A. Biochemistry 29, 10018, (1990). View articlePMID: 2125487

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