1jkx
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase
PDB structure
Accession | 1jkx |
Experiment type | X-ray |
Resolution | 1.6 Å |
Chains | A, B, C, D |
Released | 30 November 2001 |
Chain A ( P08179)
Domains in the chain
PDB: Chain A
Representative families
Representative domains
Chain B ( P08179)
Domains in the chain
PDB: Chain B
Representative families
Representative domains
Chain C ( P08179)
Domains in the chain
PDB: Chain C
Representative families
Representative domains
Chain D ( P08179)
Domains in the chain
PDB: Chain D
Representative families
Representative domains
References
1. Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase. Greasley, S.E., Marsilje, T.H., Cai, H., Baker, S., Benkovic, S.J., Boger, D.L., Wilson, I.A. Biochemistry 40, 13538-13547, (2001). View articlePMID: 11695901
2. Functionalized analogues of 5,8,10-trideazafolate: Development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase Boger, D.L., Haynes, N.-E., Warren, M.S., Ramcharan, J., Kitos, P.A., Benkovic, S.J. Bioorg. Med. Chem. 5, 1839-1846, (1997). View article