1n8r

Structure of large ribosomal subunit in complex with virginiamycin M

PDB structure
Accession
1n8r
Experiment typeX-ray
Resolution3 Å
Chains1, 2, 3, 4, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z
Released22 July 2003

Chain 1 ( P60619)

Domains in the chain
17310203040506070
204060RTGRFGPRYGLKIRVRVADVEIKHKKKHKCPVCGFKKLKRAGTGIWMCGHCGYKIAGGCYQPETVAGKAVMKA
PDB: Chain 1

Chain 2 ( P32410)

Domains in the chain
156510152025303540455055
2040TGAGTPSQGKKNTTTHTKCRRCGEKSYHTKKKVCSSCGFGKSAKRRDYEWQSKAGE
PDB: Chain 2

Chain 3 ( P22452)

Domains in the chain
14851015202530354045
2040GKKSKATKKRLAKLDNQNSRVPAWVMLKTDEVQRNHKRRHWRRNDTDE
PDB: Chain 3

Chain 4 ( P32411)

Domains in the chain
192102030405060708090
20406080MQMPRRFNTYCPHCNEHQEHEVEKVRSGRQTGMKWIDRQRERNSGIGNDGKFSKVPGGDKPTKKTDLKYRCGECGKAHLREGWRAGRLEFQE
PDB: Chain 4

Chain D ( P20279)

Domains in the chain

Chain E ( P12735)

Domains in the chain

Chain H ( P12743)

Domains in the chain

Chain J ( P60617)

Domains in the chain

Chain K ( P29198)

Domains in the chain

Chain L ( P22450)

Domains in the chain

Chain M ( P12737)

Domains in the chain

Chain N ( P60618)

Domains in the chain

Chain O ( P14123)

Domains in the chain
118620406080100120140160180
50100150
PDB: Chain O
Ribosomal_L18_L5e
Representative domains
Ribosomal_L18_L5e

Chain P ( P12733)

Domains in the chain
1115102030405060708090100110
50100SKTNPRLSSLIADLKSAARSSGGAVWGDVAERLEKPRRTHAEVNLGRIERYAQEDETVVVPGKVLGSGVLQKDVTVAAVDFSGTAETKIDQVGEAVSLEQAIENNPEGSHVRVIR
PDB: Chain P

Chain R ( P12734)

Domains in the chain
195102030405060708090
50PSSNGPLEGTRGKLKNKPRDRGTSPPQRAVEEFDDGEKVHLKIDPSVPNGRFHPRFDGQTGTVEGKQGDAYKVDIVDGGKEKTIIVTAAHLRRQE
PDB: Chain R

Chain S ( P10970)

Domains in the chain

Chain T ( P12732)

Domains in the chain
1841020304050607080
20406080SWDVIKHPHVTEKAMNDMDFQNKLQFAVDDRASKGEVADAVEEQYDVTVEQVNTQNTMDGEKKAVVRLSEDDDAQEVASRIGVF
PDB: Chain T

Chain V ( P14116)

Domains in the chain

Chain W ( P10971)

Domains in the chain
170510152025303540455055606570
204060TVLHVQEIRDMTPAEREAELDDLKTELLNARAVQAAGGAPENPGRIKELRKAIARIKTIQGEEGDLQENE
PDB: Chain W

Chain Y ( P18138)

Domains in the chain
191102030405060708090
20406080SASDFEERVVTIPLRDARAEPNHKRADKAMILIREHLAKHFSVDEDAVRLDPSINEAAWARGRANTPSKIRVRAARFEEEGEAIVEAETAE
PDB: Chain Y

Chain Z ( P12736)

Domains in the chain

References

1. Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit Hansen, J., Moore, P.B., Steitz, T.A. J. Mol. Biol. 330, 1061-1075, (2003). View articlePMID: 12860128

2. The complete atomic structure of the large ribosomal subunit at 2.4 A resolution Ban, N., Nissen, P., Hansen, J., Moore, P.B., Steitz, T.A. Science 289, 905-920, (2000). View article

3. The structural basis of ribosome activity in peptide bond synthesis Nissen, P., Hansen, J., Ban, N., Moore, P.B., Steitz, T.A. Science 289, 920-930, (2000). View article

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