Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-673
Accession | 3acx |
Experiment type | X-ray |
Resolution | 1.31 Å |
Chains | A |
Released | 24 November 2010 |
Chain A ( A9JQL9)
References
1. Mechanism of action and inhibition of dehydrosqualene synthase Lin, F.Y., Liu, C.I., Liu, Y.L., Zhang, Y., Wang, K., Jeng, W.Y., Ko, T.P., Cao, R., Wang, A.H.J., Oldfield, E. Proc. Natl. Acad. Sci. U.S.A. 107, 21337-21342, (2010). View articlePMID: 21098670
2. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Liu, C.I., Liu, G.Y., Song, Y., Yin, F., Hensler, M.E., Jeng, W.Y., Nizet, V., Wang, A.H., Oldfield, E. Science 319, 1391-1394, (2008). View articlePMID: 18276850
3. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. Song, Y., Liu, C.I., Lin, F.Y., No, J.H., Hensler, M., Liu, Y.L., Jeng, W.Y., Low, J., Liu, G.Y., Nizet, V., Wang, A.H., Oldfield, E. J. Med. Chem. 52, 3869-3880, (2009). View articlePMID: 19456099