3acx

Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-673

PDB structure
Accession
3acx
Experiment typeX-ray
Resolution1.31 Å
ChainsA
Released24 November 2010

Chain A ( A9JQL9)

Domains in the chain

References

1. Mechanism of action and inhibition of dehydrosqualene synthase Lin, F.Y., Liu, C.I., Liu, Y.L., Zhang, Y., Wang, K., Jeng, W.Y., Ko, T.P., Cao, R., Wang, A.H.J., Oldfield, E. Proc. Natl. Acad. Sci. U.S.A. 107, 21337-21342, (2010). View articlePMID: 21098670

2. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Liu, C.I., Liu, G.Y., Song, Y., Yin, F., Hensler, M.E., Jeng, W.Y., Nizet, V., Wang, A.H., Oldfield, E. Science 319, 1391-1394, (2008). View articlePMID: 18276850

3. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. Song, Y., Liu, C.I., Lin, F.Y., No, J.H., Hensler, M., Liu, Y.L., Jeng, W.Y., Low, J., Liu, G.Y., Nizet, V., Wang, A.H., Oldfield, E. J. Med. Chem. 52, 3869-3880, (2009). View articlePMID: 19456099

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