3fci

Complex of UNG2 and a fragment-based designed inhibitor

PDB structure
Accession
3fci
Experiment typeX-ray
Resolution1.27 Å
ChainsA
Released28 April 2009

References

1. Impact of linker strain and flexibility in the design of a fragment-based inhibitor Chung, S., Parker, J.B., Bianchet, M., Amzel, L.M., Stivers, J.T. Nat. Chem. Biol. 5, 407-413, (2009). View articlePMID: 19396178

2. Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development Jiang, T.L., Krosky, D.J., Seiple, L., Stivers, J.T. J. Am. Chem. Soc. 127, 17412, (2005).

3. Mimicking damaged DNA with a small molecule inhibitor of human UNG2. Krosky, D.J., Bianchet, M.A., Seiple, L., Chung, S., Amzel, L.M., Stivers, J.T. Nucleic Acids Res. 34, 5872, (2006).

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