3fci
Complex of UNG2 and a fragment-based designed inhibitor
PDB structure
Accession | 3fci |
Experiment type | X-ray |
Resolution | 1.27 Å |
Chains | A |
Released | 28 April 2009 |
Chain A ( P13051)
Domains in the chain
PDB: Chain A
Representative families
Representative domains
References
1. Impact of linker strain and flexibility in the design of a fragment-based inhibitor Chung, S., Parker, J.B., Bianchet, M., Amzel, L.M., Stivers, J.T. Nat. Chem. Biol. 5, 407-413, (2009). View articlePMID: 19396178
2. Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development Jiang, T.L., Krosky, D.J., Seiple, L., Stivers, J.T. J. Am. Chem. Soc. 127, 17412, (2005).
3. Mimicking damaged DNA with a small molecule inhibitor of human UNG2. Krosky, D.J., Bianchet, M.A., Seiple, L., Chung, S., Amzel, L.M., Stivers, J.T. Nucleic Acids Res. 34, 5872, (2006).