3jap

Structure of a partial yeast 48S preinitiation complex in closed conformation

PDB structure
Accession
3jap
Experiment typeCryo-EM
Resolution4.9 Å
ChainsA, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, o, p, q, r, s
Released12 August 2015

Chain a ( Q6CS01)

Domains in the chain
1119102030405060708090100110
50100
PDB: Chain a

Chain A ( Q6CN12)

Domains in the chain

Chain b ( Q6CNL2)

Domains in the chain
1821020304050607080
20406080MVLVQDLLHPTAASEARKHKLKTLVQSPRSHFLDVKCPGCLNITTVFSHAQTAVTCESCSTVLCTPTGGKAKLSEGTSFRRK
PDB: Chain b

Chain B ( Q6CWD0)

Domains in the chain

Chain c ( P33285)

Domains in the chain
1675101520253035404550556065
204060MDTKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDTTRTIVRNVKGPVREGDILVLMESEREARRLR
PDB: Chain c

Chain d ( Q6CPG3)

Domains in the chain
156510152025303540455055
2040MAHENVWYSHPRKFGKGSRQCRISGSHSGLIRKYGLNIDRQSFREKANDIGFYKYR
PDB: Chain d

Chain e ( Q6CUH5)

Domains in the chain
16351015202530354045505560
204060MGKVHGSLARAGKVKSQTPKVEKQEKPKQPKGRAYKRLLYTRRFVNVTLTNGKRKMNPSPSSQ
PDB: Chain e

Chain f ( P69061)

Chain F ( Q6CRA3)

Domains in the chain

Chain g ( Q6CNI7)

Domains in the chain

Chain G ( Q6CM04)

Domains in the chain

Chain h ( P0CX86)

Domains in the chain
12524681012141618202224
1020MRAKWRKKRTRRLKRKRRKVRARSK
PDB: Chain h

Chain H ( Q6CTD6)

Domains in the chain
119020406080100120140160180
50100150
PDB: Chain H

Chain i ( P38912)

Domains in the chain

Chain I ( Q6CMG3)

Domains in the chain

Chain J ( Q6CM18)

Chain K ( Q6CVZ5)

Domains in the chain

Chain l ( P09064)

Domains in the chain

Chain L ( Q6CX80)

Domains in the chain

Chain m ( P32911)

Domains in the chain
1108102030405060708090100
50100MSIENLKSFDPFADTGDDETATSNYIHIRIQQRNGRKTLTTVQGVPEEYDLKRILKVLKKDFACNGNIVKDPEMGEIIQLQGDQRAKVCEFMISQLGLQKKNIKIHGF
PDB: Chain m

Chain M ( Q6CLU4)

Domains in the chain

Chain o ( P38249)

Domains in the chain

Chain O ( P27069)

Domains in the chain
1137102030405060708090100110120130
50100
PDB: Chain O

Chain p ( P32497)

Domains in the chain

Chain P ( Q6CKV4)

Domains in the chain

Chain q ( P40217)

Domains in the chain
134750100150200250300
100200300
PDB: Chain q

Chain Q ( Q875N2)

Domains in the chain
114320406080100120140
50100
PDB: Chain Q

Chain R ( Q6CWU3)

Domains in the chain
1136102030405060708090100110120130
50100
PDB: Chain R

Chain s ( A6ZZ25)

Domains in the chain
1525101520253035404550
2040VHKSVAERKNWHKYGSEKGSPAGPSAVTARLGEEVELRLSRNWKQAEEERIQ
PDB: Chain s

Chain S ( Q6CWT9)

Domains in the chain
114620406080100120140
50100
PDB: Chain S

Chain T ( Q6CXM0)

Domains in the chain
114420406080100120140
50100
PDB: Chain T

Chain U ( Q6CIM1)

Domains in the chain

Chain V ( Q6CXT6)

Domains in the chain
1871020304050607080
20406080MENDKGQLVELYVPRKCSATNRIIKAKDHSSVQINIAQVDEEGRAIPGEYVTYALSGYIRARGEADDSLNRLAQQDGLLKNVWSYSR
PDB: Chain V

Chain W ( Q6CW21)

Domains in the chain
1130102030405060708090100110120130
50100
PDB: Chain W

Chain X ( F2Z602)

Domains in the chain

Chain Y ( Q6CU44)

Domains in the chain
1135102030405060708090100110120130
50100
PDB: Chain Y

Chain Z ( Q6CW78)

Domains in the chain
1108102030405060708090100
50100MPPKQQLSKAAKAAAAMAGGKKSKKKWSKKSHKDKAKHAVVLDQDKFDRIMKEAPTYRYVSVSVLVDRFKLGGSLARVALRHLENEGIIKPVSKHSKQAIYTRATASE
PDB: Chain Z

References

1. Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex. Llacer, J.L., Hussain, T., Marler, L., Aitken, C.E., Thakur, A., Lorsch, J.R., Hinnebusch, A.G., Ramakrishnan, V. Mol. Cell 59, 399-412, (2015). View articlePMID: 26212456

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.