4h6j

Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction.

PDB structure
Accession
4h6j
Experiment typeX-ray
Resolution1.52 Å
ChainsA, B
Released5 December 2012

Chain A ( Q16665)

Domains in the chain
1113102030405060708090100110
50100GSDSKTFLSEHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQH
PDB: Chain A
Hypoxia_neural_regulators
Representative families
Hypoxia_neural_regulators

Chain B ( P27540)

Domains in the chain
1116102030405060708090100110
50100GSVCQPTRFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQE
PDB: Chain B

References

1. Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction. Cardoso, R., Love, R., Nilsson, C.L., Bergqvist, S., Nowlin, D., Yan, J., Liu, K.K., Zhu, J., Chen, P., Deng, Y.L., Dyson, H.J., Greig, M.J., Brooun, A. Protein Sci. 21, 1885-1896, (2012). View articlePMID: 23033253

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