# STOCKHOLM 1.0 #=GF ID Insulin #=GF AC PF00049.23 #=GF DE Insulin/IGF/Relaxin family #=GF PI ins; #=GF AU Eddy SR;0000-0001-6676-4706 #=GF SE Overington enriched #=GF GA 23.00 23.00; #=GF TC 23.00 23.00; #=GF NC 22.90 22.90; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch --cpu 4 -Z 81514348 -E 1000 HMM pfamseq #=GF TP Domain #=GF WK Insulin/IGF/Relaxin_family #=GF CL CL0239 #=GF DR INTERPRO; IPR016179; #=GF DR PROSITE; PDOC00235; #=GF DR PRINTS; PR00276; #=GF DR SCOP; 1cph; sf; #=GF DR HOMSTRAD; ins; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC Superfamily includes insulins; relaxins; insulin-like growth #=GF CC factor; and bombyxin. All are secreted regulatory hormones. #=GF CC Disulfide rich, all-alpha fold. Alignment includes B chain, #=GF CC linker (which is processed out of the final product), and A #=GF CC chain. #=GF SQ 28 #=GS INS_CAVPO/28-109 AC P01329.2 #=GS INS_OCTDE/28-106 AC P17715.2 #=GS INS1_MOUSE/28-107 AC P01325.1 #=GS INS1_MOUSE/28-107 DR PDB; 7QHP T; -1-11; #=GS INS1_MOUSE/28-107 DR PDB; 3WS3 E; 1-7; #=GS INS1_MOUSE/28-107 DR PDB; 3WS3 F; 1-7; #=GS INS_RODSP/27-107 AC P21563.1 #=GS INS_AOTTR/28-107 AC P67972.1 #=GS INS_CANLF/28-109 AC P01321.1 #=GS INS_BOVIN/28-104 AC P01317.2 #=GS INS_BOVIN/28-104 DR PDB; 1BPH B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 1CPH B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4IHN A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6QRK A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4M4H A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 5MIZ B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6QRH B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 2INS A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6ZI8 D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4M4F B; 4-29; #=GS INS_BOVIN/28-104 DR PDB; 5AZZ B; 4-29; #=GS INS_BOVIN/28-104 DR PDB; 4E7V 4; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4E7T A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 1CPH A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V I; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 5AZZ A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4M4F C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 5KQV J; 5-21; #=GS INS_BOVIN/28-104 DR PDB; 4M4J B; 4-29; #=GS INS_BOVIN/28-104 DR PDB; 4E7V R; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 1PID C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 5KQV I; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6KH9 A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V B; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 2ZP6 A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4M4H D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4M4L D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4E7V K; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7U D; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4E7V X; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4M4J C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4M4M C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4M4I C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V F; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4E7V T; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4E7V N; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4E7V G; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V Z; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 6OR0 A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 1DPH A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V U; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 2BN3 B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6OR0 B; 4-29; #=GS INS_BOVIN/28-104 DR PDB; 4M4J D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4M4L B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 1DPH B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4E7U A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V M; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 7ELJ A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V 2; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4M4I A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7U B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6QQ7 A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4IDW D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 1BPH A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 1PID A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7T B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6QQ7 B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4E7V P; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4E7V Q; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V S; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 2BN1 A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 1PID D; 4-25; #=GS INS_BOVIN/28-104 DR PDB; 4M4M B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4E7V V; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 6KH8 A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4IHN B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4M4I D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4BS3 A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6KH9 B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 2ZP6 D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4IDW A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 5KQV B; 5-21; #=GS INS_BOVIN/28-104 DR PDB; 4BS3 B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6ZHB B; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 6Q8Q B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 7ELJ B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6KH8 B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4IDW B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4M4I B; 4-29; #=GS INS_BOVIN/28-104 DR PDB; 4I5Y A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6ZI8 C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V 3; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 2A3G B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4M4F A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V 6; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 2A3G D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6KHA A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7U C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6QRH A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V D; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 6QRK B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 2A3G A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V E; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6Q8Q A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4M4F D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 1APH B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 2INS B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4E7V L; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4M4L C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4M4M A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 2INS C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 2BN1 B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6ZI8 B; 4-29; #=GS INS_BOVIN/28-104 DR PDB; 4E7V O; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6ZHB A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 5MIZ A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 2A3G C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6ZHB C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4IDW C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6ZHB D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 1APH A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 2ZP6 C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V Y; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 5KQV A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 6KHA B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4E7T D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6QQG B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4M4L A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 1HO0 A; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 2INS D; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 2BN3 A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4I5Z A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V H; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 4M4J A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 2ZP6 B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4M4H B; 4-29; #=GS INS_BOVIN/28-104 DR PDB; 4I5Z B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 6QQG A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V J; 4-28; #=GS INS_BOVIN/28-104 DR PDB; 6ZI8 A; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V 1; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4I5Y B; 4-30; #=GS INS_BOVIN/28-104 DR PDB; 4E7T C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4M4H C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V C; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 1PID B; 4-25; #=GS INS_BOVIN/28-104 DR PDB; 4E7V W; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4E7V 5; 1-20; #=GS INS_BOVIN/28-104 DR PDB; 4M4M D; 4-30; #=GS INS1_XENLA/27-105 AC P12706.2 #=GS INS_MYXGL/30-114 AC P01342.1 #=GS INS_ONCKE/26-104 AC P04667.2 #=GS INS_CYPCA/27-107 AC P01335.1 #=GS INS_LOPAM/29-115 AC P69045.1 #=GS ILP_BRACL/25-100 AC P22334.1 #=GS IGF_MYXGL/41-102 AC P22618.1 #=GS IGF1_BOVIN/52-110 AC P07455.2 #=GS IGF2_BOVIN/30-84 AC P07456.4 #=GS C6GBY8_ONCMY/53-110 AC C6GBY8.1 #=GS REL1_HUMAN/32-185 AC P04808.1 #=GS RELX_PIG/31-182 AC P01348.1 #=GS REL1_RAT/33-186 AC P01347.1 #=GS BXB1_BOMMO/26-88 AC P26733.1 #=GS BXB5_BOMMO/27-88 AC P26739.1 #=GS BXB1_SAMCY/24-91 AC P33721.1 #=GS BXC1_BOMMO/24-89 AC P15410.2 #=GS BXA2_BOMMO/26-89 AC P15411.1 #=GS BXA2_BOMMO/26-89 DR PDB; 1BON A; 1-20; #=GS BXA2_BOMMO/26-89 DR PDB; 1BOM A; 1-20; #=GS BXA3_BOMMO/26-92 AC P26726.1 #=GS BXD1_BOMMO/24-90 AC P26736.1 #=GS INS_CHICK/28-106 AC P67970.1 INS_CAVPO/28-109 RHLCGSNLVETLY.SVC...QD......D.GFFY.IP...KDRRELEDPQVEQTEL......................................................................GMGLGAGGLQPLAL.EMAL......QKRG..IVDQCCTGTCTRHQLQSYC INS_OCTDE/28-106 QHLCGSNLVEALY.MTC...GR......S.GF.Y.RP...HDRRELEDLQVEQAE........................................................................LGLEAGGLQPSAL.EMIL......QKRG..IVDQCCNNICTFNQLQNYC INS1_MOUSE/28-107 QHLCGPHLVEALY.LVC...GE......R.GFFYT.P...KSRREVEDPQVEQLE........................................................................LGGSPGDLQTLAL.EVAR......QKRG..IVDQCCTSICSLYQLENYC #=GR INS1_MOUSE/28-107 SS XXXXXXXXXXXXX.XXX...XX......X.XXXXX.X...XXXXXXXXXXXXXXX........................................................................XXXXXXXXBXXXX.XXXX......XXXX..XXXXXXXXXXXX------S INS_RODSP/27-107 QHLCGSHLVEALYILVC...GE......R.GFFYT.P...MSRREVEDPQVGQVEL......................................................................GAGPGAGSEQTLAL.EVAR......QAR...IVQQCTSGICSLYQ.ENYC INS_AOTTR/28-107 QHLCGPHLVEALY.LVC...GE......R.GFFY.AP...KTRREAEDLQVGQVE........................................................................LGGGSITGSLPPL.EGPM......QKRG..VVDQCCTSICSLYQLQNYC INS_CANLF/28-109 QHLCGSHLVEALY.LVC...GE......R.GFFYT.P...KARREVEDLQVRDVEL......................................................................AGAPGEGGLQPLAL.EGAL......QKRG..IVEQCCTSICSLYQLENYC INS_BOVIN/28-104 QHLCGSHLVEALY.LVC...GE......R.GFFYT.P...KARREVEGPQVGALEL......................................................................AGGPGAGGLEGPPQ............KRG..IVEQCCASVCSLYQLENYC #=GR INS_BOVIN/28-104 SS BHHHTHHHHHHHH.HHH...GG......G.TEEES.T...T-XXXXXXXXXXXXXX......................................................................XXXXXXXXXXXXXX............XXX..HHHHHTTSTBEHHHHGGGB INS1_XENLA/27-105 QHLCGSHLVEALY.LVC...GD......R.GFFY.YP...KVKRDMEQALVSGPQ........................................................................DNELDG.MQLQPQEYQKM.......KRG..IVEQCCHSTCSLFQLESYC INS_MYXGL/30-114 GHLCGKDLVNALY.IAC...GV......R.GFFYD.P...TKMKRDTGALAAFLPLAY...................................................................AEDNESQDDESIGIN.EVLK......SKRG..IVEQCCHKRCSIYDLENYC INS_ONCKE/26-104 QHLCGSHLVDALY.LVC...GE......K.GFFYT.P......KRDVDPLIGFLSP......................................................................KSAKENE.EYPFKDQTEMM......VKRG..IVEQCCHKPCNIFDLQNYC INS_CYPCA/27-107 QHLCGSHLVDALY.LVC...GP......T.GFFYN.P......KRDVDPPLGFLPPKS...................................................................AQETEVADFAFKDHA.EVIR.......KRG..IVEQCCHKPCSIFELQNYC INS_LOPAM/29-115 QHLCGSHLVDALY.LVC...GD......R.GFFYN.P......KRDVDQLLGFLPPKSGGA.............................................................AAAGADNEVAEFAFKDQM.EMMV.......KRG..IVEQCCHRPCNIFDLQNYC ILP_BRACL/25-100 EYLCGSTLADVLS.FVC...GN......R.GY..N.S...QPRRSVSKRAIDFIS..........................................................................EQQAKDYMGAM.PHIR...R..RR.G..LVEECCYNVCDYSQLESYC IGF_MYXGL/41-102 ETLCGSELVDTLQ.FVC...DD......R.GFFFV.PQHVPPR...............................................................................................RG.AHRRS..R.ARK.G..IVEECCFKGCSLRLLEMYC IGF1_BOVIN/52-110 ETLCGAELVDALQ.FVC...GD......R.GFYFNKP...TGY................................................................................................G.SSSR...R.APQTG..IVDECCFRSCDLRRLEMYC IGF2_BOVIN/30-84 ETLCGGELVDTLQ.FVC...GD......R.GFYFSRP...SSR....................................................................................................IN...R..RSRG..IVEECCFRSCDLALLETYC C6GBY8_ONCMY/53-110 ETLCGGELVDALQ.FVC...ED......R.GFYFSRP...TSR..................................................................................................SNSR...R.SQNRG..IVEECCFRSCDLNLLEQYC REL1_HUMAN/32-185 IKLCGRELVRAQI.AIC...GMST.WSKRSLSQEDAPQ..TPR.....PVAEIVPSFINKDTETIIIMLEFIANL.....PPELKAALSERQPSLPELQQYVPALKDSNLSFEEFKKLIRNRQSEAADSNPSELKYLGLD.THSQKKRR..PYVA..LFEKCCLIGCTKRSLAKYC RELX_PIG/31-182 IKACGRELVRLWV.EIC...GSV....SW.GR..TAL.......SLEEPQLETGPPAETMPSSITKDAEILKMMLEF.VPNLPQELKATLSERQPSLRELQQSASKDSNLNFEEFKKIILNRQNEAEDKSLLELKNLGLD.KHSRK.KRLFRMT...LSEKCCQVGCIRKDIARLC REL1_RAT/33-186 IQVCGRGYARAWI.EVCG..ASV....GR.LA..L.S......QEEPAPLARQATAEVVPSFINKDAEPFDMTLKCLPNLSEERKAALSEGRAPFPELQQHAPALSDSVVSLEGFKKTFHNQLGEAEDGGPPELKYLGSD.AQSR...K.KRQSGALLSEQCCHIGCTRRSIAKLC BXB1_BOMMO/26-88 RTYCGRHLADTLA.DLCF..GVE....KRGGAQY.APY.FWTR................................................................................................QYLGSR......GKRG..VVDECCFRPCTLDVLLSYC BXB5_BOMMO/27-88 RTYCGRHLANILA.YVCF..GVE....KRGGAQY.APY..WQE...............................................................................................TY.LRSR...K..GP.G..VVDECCFRPCKLEVLKSYC BXB1_SAMCY/24-91 RRYCGRVLADTLA.YLC...PEMEEVEKRSGAQY.AR...YGW................................................................................................QSPESREGAR..GKRG..VVDECCYNSCTLDVLLSYC BXC1_BOMMO/24-89 QFYCGDFLARTMS.SLCW..SDM...QKRSGSQY.AGY.GWPW.............................................................................................LPPF.SSSR......GKRG..IVDECCYRPCTIDVLMSYC BXA2_BOMMO/26-89 HTYCGRHLARTMA.DLCW..EEGV..DKRSDAQF.ASY.GSAW.............................................................................................LMPY.SAGR.........G..IVDECCLRPCSVDVLLSYC #=GR BXA2_BOMMO/26-89 SS XXXXXXXXXXXXX.XXXX..XXXX..XXXXXXXX.XXX.XXXX.............................................................................................XXXX.XXXX.........-..THHHHTTS--TTTTTTTT- BXA3_BOMMO/26-92 HTYCGRHLARTLA.NLCWEAGVD....KRSDAQYV.SY.GSAW.............................................................................................LMPY.SEGR......GKRG..IVDECCLRPCSVDVLLSYC BXD1_BOMMO/24-90 HIYCGRYLAYKMA.DLCW..RAGF..EKRSVAHY.AGY.GWPL.............................................................................................LPSL.SEER......GKRG..IADECCLQPCTNDVLLSYC INS_CHICK/28-106 QHLCGSHLVEALY.LVC...GE......R.GFFY.SP...KARRDVEQPLVSSPL...........................................................................RGEAGVLPFQ.QEEY...E.KVKRG..IVEQCCHNTCSLYQLENYC #=GC SS_cons BHHHTHHHHHHHH.HHHX..GGXX..XXGXTEEESXTX.XTXX............................................................................................BXXXX.XXXX.........-..CHHHHTTSTBCCCCCCCCC #=GC seq_cons ppLCGscLV-sLh.hVC...G-......R.GFaY..P...hsh.......ht....................................................................................h....ptt+......tKRG..IV-pCChpsColtpLpsYC //