Family I71

Family

Summary Holotypes Alignment Tree Genomes Structure Literature Architecture

Summary for family I71

NameInhibitor family I71 (falstatin family)
Family type peptidaseI71.001 - falstatin (Plasmodium falciparum), MEROPS Accession MER0061092 (inhibitor unit: 1-413)
Content of familyInhibitor family I71 contains cysteine peptidase inhibitors.
History Identifier created: MEROPS 7.7 (23 January 2007)
Pandey et al. (2006) showed that in some developmental stages, the malaria parasite (Plasmodium falciparum) expresses an inhibitor of cysteine peptidases, termed falstatin. In its merozoite stage, Plasmodium falciparum invades host erythrocytes and feeds on haemoglobin that it degrades with peptidases including several cysteine peptidase from family C1. Falstatin was not found in trophozoites, the stage at which the cysteine protease activity of P. falciparum is maximal, however.
Peptidases inhibitedFalstatin inhibits cysteine peptidases predominantly from family C1 but also calpain-1 (C02.001) from family C2 (Pandey et al., 2006).
Molecular structureNo tertiary structure has been solved, but limited sequence similarity suggests a relationship with members of family I42 (chagasin).
Clanunassigned
Distribution of family Bacteria details  
Archaea -  
Protozoa details  
Fungi -  
Plants details  
Animals details  
Viruses -  
Biological functionsFalstatin is present in the schizont, merozoite and ring stages of the malaria parasite, but not in the trophozoite stage where activity of the Plasmodium cysteine endopeptidases is maximal. Falstatin is released upon rupture of the mature schizont and may be important for inhibition of host peptidases during erythrocyte invasion (Pandey et al., 2006).
Statistics for family I71Sequences:163
Identifiers:1
Identifiers with PDB entries:1
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Other databases INTERPRO IPR024321
PFAM PF12628
Inhibitors and Homologues MEROPS ID Structure
falstatinI71.001Yes
Family I71 non-peptidase homologuesnon-peptidase homologue-
Family I71 unassigned peptidasesunassigned-