$VAR1 = undef;

Summary for peptidase M10.009: matrix metallopeptidase-12

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

Names
MEROPS Namematrix metallopeptidase-12
Other namesmacrophage elastase, matrix metalloproteinase 12, metalloelastase, MMP-12
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.009
Holotypematrix metallopeptidase-12 (Mus musculus), Uniprot accession P34960 (peptidase unit: 91-272), MERNUM MER0001090
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00162
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.65
EnzymologyBRENDA database
Proteolytic eventsCutDB database (94 cleavages)
Activity statushuman: active (Shapiro et al., 2004)
mouse: active (Shapiro et al., 1992)
PhysiologyRole in turnover of extracellular matrix proteins.
Pharmaceutical relevanceDrug target for prevention of pathological tissue damage.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP12
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/pa/-/gScissile bondl/-/-/- (based on 342 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 69 32 55 84 12 57 70 47
Pro 21 94 21 23 14 11 15 34
Ala 39 73 66 64 41 43 69 63
Val 27 19 11 9 29 22 17 18
Leu 25 30 45 9 93 22 22 27
Ile 5 5 5 2 15 12 6 16
Met 3 0 8 5 4 3 2 2
Phe 5 2 15 8 12 9 7 11
Tyr 4 1 7 4 17 8 10 5
Trp 1 1 1 2 2 10 4 0
Ser 13 16 10 13 17 26 28 25
Thr 12 9 10 10 10 16 19 13
Cys 3 4 3 10 13 4 2 5
Asn 12 5 7 19 6 6 3 8
Gln 12 10 21 7 8 16 8 8
Asp 10 4 8 5 15 9 8 8
Glu 14 7 15 18 8 19 20 21
Lys 23 11 21 27 17 27 12 15
Arg 23 9 5 17 4 17 15 13
His 5 3 6 6 4 4 4 2
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP12 11q22.2-q22.3 ENSG00000110347 4321 MMP12 601046
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp12 9:A1 ENSMUSG00000049723 17381 MGI:97005