$VAR1 = undef;
Summary for peptidase M10.009: matrix metallopeptidase-12
Names | |
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MEROPS Name | matrix metallopeptidase-12 |
Other names | macrophage elastase, matrix metalloproteinase 12, metalloelastase, MMP-12 |
Domain architecture |
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MEROPS Classification | |
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Classification | Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.009 |
Holotype | matrix metallopeptidase-12 (Mus musculus), Uniprot accession P34960 (peptidase unit: 91-272), MERNUM MER0001090 |
History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
Activity | |||
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Catalytic type | Metallo | ||
Peplist | Included in the Peplist with identifier PL00162 | ||
NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.65 | ||
Enzymology | BRENDA database | ||
Proteolytic events | CutDB database (94 cleavages) | ||
Activity status | human: active (Shapiro et al., 2004) mouse: active (Shapiro et al., 1992) | ||
Physiology | Role in turnover of extracellular matrix proteins. | ||
Pharmaceutical relevance | Drug target for prevention of pathological tissue damage. | ||
Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/MMP12 | |
Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
Cleavage pattern | -/pa/-/gl/-/-/- (based on 342 cleavages) |
Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Human genetics | ||||||
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Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
MMP12 | 11q22.2-q22.3 | ENSG00000110347 | 4321 | MMP12 | 601046 | |
Mouse genetics | ||||||
Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
Mmp12 | 9:A1 | ENSMUSG00000049723 | 17381 | MGI:97005 |