$VAR1 = undef;

Summary for peptidase M41.001: FtsH peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS NameFtsH peptidase
Other namesHflB protease, filamentation temperature sensitive H peptidase, MrsC g.p. (Escherichia coli), tolZ g.p. (Escherichia coli)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(D) >> Family M41 >> Subfamily (none) >> M41.001
HolotypeFtsH peptidase (Escherichia coli), Uniprot accession P0AAI3 (peptidase unit: 365-647), MERNUM MER0001620
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00253
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyProposed role in proteolytic quality control of regulatory molecules and membrane proteins, in yeast.
Other databases PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR23076:SF37
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/lScissile bond-/-/-/- (based on 24 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 0 0 0 1 1 1
Pro 2 1 1 0 1 0 2 3
Ala 3 3 3 2 2 1 1 1
Val 1 1 2 1 1 3 2 3
Leu 5 3 6 8 4 5 3 5
Ile 1 2 0 1 0 1 1 1
Met 1 1 1 1 1 0 1 0
Phe 2 2 1 1 2 0 1 0
Tyr 0 0 0 1 1 1 1 2
Trp 1 0 1 1 1 1 1 1
Ser 2 3 2 1 5 1 2 2
Thr 1 1 3 0 0 1 1 0
Cys 0 0 0 0 0 0 0 0
Asn 1 1 0 0 1 0 0 0
Gln 2 2 3 1 1 2 4 2
Asp 0 1 0 0 0 0 0 0
Glu 0 2 1 3 1 4 3 3
Lys 0 0 0 2 2 2 0 0
Arg 1 0 0 1 1 0 0 0
His 0 0 0 0 0 1 0 0