$VAR1 = undef;
Summary for peptidase M50.001: site 2 peptidase
Names | |
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MEROPS Name | site 2 peptidase |
Other names | membrane-bound transcription factor protease site 2, MBTPS2 g.p. (Homo sapiens), S2P protease, site-2 protease, sterol regulatory element-binding protein site 2 protease, SREBP S2 protease, S2P peptidase |
Domain architecture |
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MEROPS Classification | |
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Classification | Clan MM >> Subclan (none) >> Family M50 >> Subfamily A >> M50.001 |
Holotype | site 2 peptidase (Homo sapiens), Uniprot accession O43462 (peptidase unit: 1-519), MERNUM MER0004458 |
History | Identifier created: MEROPS 3.03 (10 September 1998) |
Activity | |||
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Catalytic type | Metallo | ||
Peplist | Included in the Peplist with identifier PL00260 | ||
NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.85 | ||
Enzymology | BRENDA database | ||
Proteolytic events | CutDB database (3 cleavages) | ||
Activity status | human: active (Rawson, 2004) mouse: active (by similarity to human) (Duncan et al., 1998) | ||
Other databases | TREEFAM | http://www.treefam.org/family/TF314478 |
Human genetics | ||||||
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Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
MBTPS2 | X | ENSG00000012174 | 51360 | MBTPS2 | 300294 | |
Mouse genetics | ||||||
Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
Mbtps2 | X:F4 | ENSMUSG00000046873 | 270669 | MGI:2444506 |