$VAR1 = undef;
Summary for peptidase S01.196: complement factor Bb
| Names | |
|---|---|
| MEROPS Name | complement factor Bb |
| Other names | activated factor B of alternative-complement-pathway C3/C5 convertase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.196 |
| Holotype | complement factor Bb (Homo sapiens), Uniprot accession P00751 (peptidase unit: 440-727), MERNUM MER0000229 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| Peplist | Included in the Peplist with identifier PL00302 | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Proteolytic events | CutDB database (2 cleavages) | ||
| Activity status | human: active (Kerr, 2004) mouse: active (Taylor et al., 1998) | ||
| Physiology | Catalytic component of C3/C5 convertase in classical pathway of complement activation. | ||
| Knockout | Factor B-deficient mice have been described (Taylor et al., 1998). | ||
| Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/Complement_factor_B | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| CFB | 6p21.3 | ENSG00000180160 | 629 | BF | 138470 | |
| Mouse genetics | ||||||
| Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
| H2-Bf | 17:B1 | ENSMUSG00000024371 | 14962 | MGI:105975 | ||
