Literature for peptidase C01.032: cathepsin L

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2024
  1. Ciaglia,T., Vestuto,V., Di Sarno,V., Musella,S., Smaldone,G., Di Matteo,F., Napolitano,V., Miranda,M.R., Pepe,G., Basilicata,M.G., Novi,S., Capolupo,I., Bifulco,G., Campiglia,P., Gomez-Monterrey,I., Snoeck,R., Andrei,G., Manfra,M., Ostacolo,C., Lauro,G. and Bertamino,A. \<br\>Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization\<br\>Eur J Med Chem (2024) 266, 116128. PubMed  Europe PubMed DOI  I
  2. Deng,W., Hu,X., Tian,X., Zhang,Y., Shang,W., Zhang,L. and Shang,L. \<br\>Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L\<br\>J Med Chem (2024) PubMed  Europe PubMed DOI  I
  3. Falke,S., Lieske,J., Herrmann,A., Loboda,J., Karnicar,K., Gunther,S., Reinke,P.Y.A., Ewert,W., Usenik,A., Lindic,N., Sekirnik,A., Dretnik,K., Tsuge,H., Turk,V., Chapman,H.N., Hinrichs,W., Ebert,G., Turk,D. and Meents,A. \<br\>Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors\<br\>J Med Chem (2024) PubMed  Europe PubMed DOI  I
  4. Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X. \<br\>Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19\<br\>Med (2024) 5, 169-171. PubMed  Europe PubMed DOI  I
  5. Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X. \<br\>Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19\<br\>Med (2024) 5, 42-61. PubMed  Europe PubMed DOI  I
  6. Xie,X., Lan,Q., Zhao,J., Zhang,S., Liu,L., Zhang,Y., Xu,W., Shao,M., Peng,J., Xia,S., Zhu,Y., Zhang,K., Zhang,X., Zhang,R., Li,J., Dai,W., Ge,Z., Hu,S., Yu,C., Wang,J., Ma,D., Zheng,M., Yang,H., Xiao,G., Rao,Z., Lu,L., Zhang,L., Bai,F., Zhao,Y., Jiang,S. and Liu,H. \<br\>Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1\<br\>Signal Transduct Target Ther (2024) 9, 54. PubMed  Europe PubMed DOI  PMC  EPMC  I
  7. Zhou,W., You,B., Zhao,X., Si,S., Li,Y. and Zhang,J. \<br\>Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors\<br\>SLAS Discov (2024) 29, 100153. PubMed  Europe PubMed DOI  I
  8. 2023
  9. Doijen,J., Temmerman,K., Van den Eynde,C., Diels,A., Van den Broeck,N., Van Gool,M., Heo,I., Jaensch,S., Zwaagstra,M., Diosa Toro,M., Chiu,W., De Jonghe,S., Leyssen,P., Bojkova,D., Ciesek,S., Cinatl,J., Verschueren,L., Buyck,C., van Kuppeveld,F., Neyts,J., Van Loock,M. and Van Damme,E. \<br\>Identification of Z-Tyr-Ala-CHN(2), a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2\<br\>Microorganisms (2023) 11, PubMed  Europe PubMed DOI  PMC  EPMC  I
  10. Huang,H., Zhang,Y., Xu,X., Liu,Y., Zhao,J., Ma,L., Lei,J., Ge,W., Li,N., Ma,E., Li,Y. and Yuan,L. \<br\>Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells\<br\>Bioorg Med Chem Lett (2023) 80, 129087. PubMed  Europe PubMed DOI  I
  11. Li,Y., Wang,K., Sun,H., Wu,S., Wang,H., Shi,Y., Li,X., Yan,H., Yang,G., Wu,M., Li,Y., Ding,X., Si,S., Jiang,J., Du,Y., Li,Y. and Hong,B. \<br\>Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2\<br\>Antiviral Res (2023) 214, 105606. PubMed  Europe PubMed DOI  PMC  EPMC  I
  12. Tang,T.T., Li,S.M., Pan,B.W., Xiao,J.W., Pang,Y.X., Xie,S.X., Zhou,Y., Yang,J. and Wei,Y. \<br\>Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure-Activity Relationships\<br\>Molecules (2023) 28, PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. Wang,C., Ye,X., Ding,C., Zhou,M., Li,W., Wang,Y., You,Q., Zong,S., Peng,Q., Duanmu,D., Chen,H., Sun,B. and Qiao,J. \<br\>Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry\<br\>J Agric Food Chem (2023) 71, 5535-5546. PubMed  Europe PubMed DOI  PMC  EPMC  I
  14. 2022
  15. Kwon,C.W., Yeo,S. and Chang,P.S. \<br\>Characterization and molecular docking study of cathepsin L inhibitory peptides (SnuCalCpIs) from Calotropis procera R. Br\<br\>Sci Rep (2022) 12, 5825. PubMed  Europe PubMed DOI  PMC  EPMC  I
  16. Meewan,I., Kattoula,J., Kattoula,J.Y., Skinner,D., Fajtova,P., Giardini,M.A., Woodworth,B., McKerrow,J.H., Lage de Siqueira-Neto,J., O'Donoghue,A.J. and Abagyan,R. \<br\>Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L\<br\>Pharmaceuticals (Basel) (2022) 15, PubMed  Europe PubMed DOI  PMC  EPMC  I
  17. Mondal,S., Chen,Y., Lockbaum,G.J., Sen,S., Chaudhuri,S., Reyes,A.C., Lee,J.M., Kaur,A.N., Sultana,N., Cameron,M.D., Shaffer,S.A., Schiffer,C.A., Fitzgerald,K.A. and Thompson,P.R. \<br\>Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2\<br\>J Am Chem Soc (2022) 144, 21035-21045. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  18. Yang,W.L., Li,Q., Sun,J., Huat Tan,S., Tang,Y.H., Zhao,M.M., Li,Y.Y., Cao,X., Zhao,J.C. and Yang,J.K. \<br\>Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy\<br\>Comput Struct Biotechnol J (2022) 20, 2442-2454. PubMed  Europe PubMed DOI  PMC  EPMC  I
  19. Yu,F., Pan,T., Huang,F., Ying,R., Liu,J., Fan,H., Zhang,J., Liu,W., Lin,Y., Yuan,Y., Yang,T., Li,R., Zhang,X., Lv,X., Chen,Q., Liang,A., Zou,F., Liu,B., Hu,F., Tang,X., Li,L., Deng,K., He,X., Zhang,H., Zhang,Y. and Ma,X. \<br\>Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L\<br\>Front Microbiol (2022) 13, 884034. PubMed  Europe PubMed DOI  PMC  EPMC  I
  20. 2021
  21. Breidenbach,J., Lemke,C., Pillaiyar,T., Schakel,L., Al Hamwi,G., Diett,M., Gedschold,R., Geiger,N., Lopez,V., Mirza,S., Namasivayam,V., Schiedel,A.C., Sylvester,K., Thimm,D., Vielmuth,C., Phuong Vu,L., Zyulina,M., Bodem,J., Gutschow,M. and Muller,C.E. \<br\>Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors\<br\>Angew Chem Int Ed Engl (2021) PubMed  Europe PubMed DOI  I
  22. Hu,Y., Ma,C., Szeto,T., Hurst,B., Tarbet,B. and Wang,J. \<br\>Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses\<br\>ACS Infect Dis (2021) 7, 586-597. PubMed  Europe PubMed DOI  PMC  EPMC  I
  23. Li,Y., Ai,X., Zou,C., Liu,Y., Ma,L., Men,J., Liu,D., Sheng,L., Ruan,X., Liu,H., Li,W., Ma,E. and Yuan,L. \<br\>Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cells\<br\>Bioorg Chem (2021) 115, 105256. PubMed  Europe PubMed DOI  I
  24. Mellott,D.M., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D.H., Hsu,J., Zhu,J., Taylor,Z.W., Kocurek,K.I., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Yoon,M.C., Beck,S., Carlin,A.F., Clark,A.E., Beretta,L., Maneval,D., Hook,V., Frueh,F., Hurst,B.L., Wang,H., Raushel,F.M., O'Donoghue,A.J., de Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H. \<br\>A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells\<br\>ACS Chem Biol (2021) 16, 642-650. PubMed  Europe PubMed DOI  PMC  EPMC  I
  25. Munikishore,R., Wang,L.L., Zhang,S., Zhao,Q.S. and Zuo,Z. \<br\>An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94\<br\>Bioorg Chem (2021) 116, 105317. PubMed  Europe PubMed DOI  I
  26. Phan,H.A.T., Giannakoulias,S.G., Barrett,T.M., Liu,C. and Petersson,E.J. \<br\>Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L\<br\>Chem Sci (2021) 12, 10825-10835. PubMed  Europe PubMed DOI  PMC  EPMC  I
  27. 2020
  28. Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R. \<br\>Potential protease inhibitors and their combinations to block SARS-CoV-2\<br\>J Biomol Struct Dyn (2020) 1-15. PubMed  Europe PubMed DOI  PMC  EPMC  I
  29. Arafet,K., Gonzalez,F.V. and Moliner,V. \<br\>Quantum mechanics/molecular mechanics studies of the mechanism of cysteine proteases inhibition by dipeptidyl nitroalkenes\<br\>Chemistry (2020) 26, 2002-2012. PubMed  Europe PubMed DOI  I
  30. Ashhurst,A.S., Tang,A.H., Fajtova,P., Yoon,M., Aggarwal,A., Stoye,A., Larance,M., Beretta,L., Drelich,A., Skinner,D., Li,L., Meek,T.D., McKerrow,J.H., Hook,V., Tseng,C.K., Turville,S., Gerwick,W.H., O'Donoghue,A.J. and Payne,R.J. \<br\>Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L\<br\>bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  31. Cianni,L., Rocho,F.D.R., Rosini,F., Bonatto,V., Ribeiro,J.F.R., Lameira,J., Leitao,A., Shamim,A. and Montanari,C.A. \<br\>Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases\<br\>Bioorg Chem (2020) 101, 104039. PubMed  Europe PubMed DOI  I
  32. Dana,D. and Pathak,S.K. \<br\>A review of small molecule inhibitors and functional probes of human cathepsin L\<br\>Molecules (2020) 25, PubMed  Europe PubMed DOI  V  I
  33. Mellott,D., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D., Hsu,J.C., Zhu,J., Taylor,Z., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Beck,S., Carlin,A.F., Clark,A.E., Berreta,L., Maneval,D., Frueh,F., Hurst,B.L., Wang,H., Kocurek,K.I., Raushel,F.M., O'Donoghue,A., Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H. \<br\>A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells\<br\>bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  34. Ribeiro,J.F.R., Cianni,L., Li,C., Warwick,T.G., De Vita,D., Rosini,F., Dos Reis Rocho,F., Martins,F.C.P., Kenny,P.W., Lameira,J., Leitao,A., Emsley,J. and Montanari,C.A. \<br\>Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor\<br\>Bioorg Med Chem (2020) 28, 115743. PubMed  Europe PubMed DOI  I
  35. Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J. \<br\>Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L\<br\>bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  36. Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J. \<br\>Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L\<br\>Sci Adv (2020) PubMed  Europe PubMed DOI  I
  37. 2019
  38. Boudreau,P.D., Miller,B.W., McCall,L.I., Almaliti,J., Reher,R., Hirata,K., Le,T., Siqueira-Neto,J.L., Hook,V. and Gerwick,W.H. \<br\>Design of gallinamide A analogs as potent inhibitors of the cysteine proteases human cathepsin L and Trypanosoma cruzi cruzain\<br\>J Med Chem (2019) 62, 9026-9044. PubMed  Europe PubMed DOI  I
  39. Dana,D., Garcia,J., Bhuiyan,A.I., Rathod,P., Joo,L., Novoa,D.A., Paroly,S., Fath,K.R., Chang,E.J. and Pathak,S.K. \<br\>Cell penetrable, clickable and tagless activity-based probe of human cathepsin L\<br\>Bioorg Chem (2019) 85, 505-514. PubMed  Europe PubMed DOI  L  I
  40. Shockey,W.A., Kieslich,C.A., Wilder,C.L., Watson,V. and Platt,M.O. \<br\>Dynamic model of protease state and inhibitor trafficking to predict protease activity in breast cancer cells\<br\>Cell Mol Bioeng (2019) 12, 275-288. PubMed  Europe PubMed DOI  PMC  EPMC  I
  41. Weiss-Sadan,T., Itzhak,G., Kaschani,F., Yu,Z., Mahameed,M., Anaki,A., Ben-Nun,Y., Merquiol,E., Tirosh,B., Kessler,B., Kaiser,M. and Blum,G. \<br\>Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation\<br\>Mol Cell Proteomics (2019) 18, 1330-1344. PubMed  Europe PubMed DOI  I
  42. Yuan,L., Liu,J., He,W., Bao,Y., Sheng,L., Zou,C., Hu,B., Ge,W., Liu,Y., Wang,J., Lin,B., Li,Y. and Ma,E. \<br\>Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells\<br\>Bioorg Chem (2019) 84, 239-253. PubMed  Europe PubMed DOI  I
  43. Yuan,L., Zou,C., Ge,W., Liu,Y., Hu,B., Wang,J., Lin,B., Li,Y. and Ma,E. \<br\>A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis\<br\>Bioorg Chem (2019) 103417. PubMed  Europe PubMed DOI  I
  44. 2018
  45. Huisman,M., Kodanko,J.P., Arora,K., Herroon,M., Alnaed,M., Endicott,J., Podgorski,I. and Kodanko,J.J. \<br\>Affinity-enhanced luminescent Re(I)- and Ru(II)-based inhibitors of the cysteine protease cathepsin L\<br\>Inorg Chem (2018) 57, 7881-7891. PubMed  Europe PubMed DOI  I
  46. 2017
  47. Dos Santos,D.A., Deobald,A.M., Cornelio,V.E., Avila,R.M.D., Cornea,R.C., Bernasconi,G.C.R., Paixao,M.W., Vieira,P.C. and Correa,A.G. \<br\>Asymmetric synthesis and evaluation of epoxy-alpha-acyloxycarboxamides as selective inhibitors of cathepsin L\<br\>Bioorg Med Chem (2017) 25, 4620-4627. PubMed  Europe PubMed DOI  I
  48. Giroud,M., Ivkovic,J., Martignoni,M., Fleuti,M., Trapp,N., Haap,W., Kuglstatter,A., Benz,J., Kuhn,B., Schirmeister,T. and Diederich,F. \<br\>Inhibition of the cysteine protease human cathepsin L by triazine nitriles: amide???heteroarene pi-stacking interactions and chalcogen bonding in the S3 pocket\<br\>ChemMedChem (2017) 12, 257-270. PubMed  Europe PubMed DOI  I
  49. Hashimoto,Y. \<br\>Gelatin zymography using leupeptin for the detection of various cathepsin L forms\<br\>Methods Mol Biol (2017) 1594, 243-254. PubMed  Europe PubMed DOI  L  I
  50. Kikuta,S., Murai,Y. and Tanaka,E. \<br\>Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons\<br\>Neurosci Lett (2017) 636, 120-126. PubMed  Europe PubMed DOI  I
  51. Kuhn,B., Tichy,M., Wang,L., Robinson,S., Martin,R.E., Kuglstatter,A., Benz,J., Giroud,M., Schirmeister,T., Abel,R., Diederich,F. and Hert,J. \<br\>Prospective evaluation of free energy calculations for the prioritization of cathepsin L inhibitors\<br\>J Med Chem (2017) 60, 2485-2497. PubMed  Europe PubMed DOI  I
  52. Li,Y.Y., Fang,J. and Ao,G.Z. \<br\>Cathepsin B and L inhibitors: a patent review (2010 - present)\<br\>Expert Opin Ther Pat (2017) 27, 643-656. PubMed  Europe PubMed DOI  V  I
  53. Parker,E.N., Odutola,S.O., Wang,Y., Strecker,T.E., Mukherjee,R., Shi,Z., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L\<br\>Bioorg Med Chem Lett (2017) 27, 1304-1310. PubMed  Europe PubMed DOI  I
  54. 2016
  55. Burton,L.J., Dougan,J., Jones,J., Smith,B.N., Randle,D., Henderson,V. and Odero-Marah,V.A. \<br\>Targeting the nuclear cathepsin L- CCAAT-displacement protein/cut homeobox transcription factor-epithelial mesenchymal transition pathway in prostate and breast cancer cells with Z-FY-CHO inhibitor\<br\>Mol Cell Biol (2016) PubMed  Europe PubMed DOI  I
  56. Giroud,M., Harder,M., Kuhn,B., Haap,W., Trapp,N., Schweizer,W.B., Schirmeister,T. and Diederich,F. \<br\>Fluorine scan of inhibitors of the cysteine protease human cathepsin L: dipolar and quadrupolar effects in the pi-stacking of fluorinated phenyl rings on peptide amide bonds\<br\>ChemMedChem (2016) 11, 1042-1047. PubMed  Europe PubMed DOI  I
  57. Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J. \<br\>Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones\<br\>RSC Adv (2016) 6, 34588-34599. DOI  I
  58. Sudhan,D.R., Pampo,C., Rice,L. and Siemann,D.W. \<br\>Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model\<br\>Int J Cancer (2016) 138, 2665-2677. PubMed  Europe PubMed DOI  I
  59. Sudhan,D.R., Rabaglino,M.B., Wood,C.E. and Siemann,D.W. \<br\>Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94\<br\>Clin Exp Metastasis (2016) 33, 461-473. PubMed  Europe PubMed DOI  I
  60. Ueki,N., Wang,W., Swenson,C., McNaughton,C., Sampson,N.S. and Hayman,M.J. \<br\>Synthesis and preclinical evaluation of a highly improved anticancer prodrug activated by histone deacetylases and cathepsin L\<br\>Theranostics (2016) 6, 808-816. PubMed  Europe PubMed DOI  PMC  EPMC  I
  61. Zhou,N., Pan,T., Zhang,J., Li,Q., Zhang,X., Bai,C., Huang,F., Peng,T., Zhang,J., Liu,C., Tao,L. and Zhang,H. \<br\>Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)\<br\>J Biol Chem (2016) 291, 9218-9232. PubMed  Europe PubMed DOI  I
  62. 2015
  63. Celis-Barros,C., Saavedra-Rivas,L., Salgado,J.C., Cassels,B.K. and Zapata-Torres,G. \<br\>Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition\<br\>J Comput Aided Mol Des (2015) 29, 37-46. PubMed  Europe PubMed DOI  I
  64. Parker,E.N., Song,J., Kishore Kumar,G.D., Odutola,S.O., Chavarria,G.E., Charlton-Sevcik,A.K., Strecker,T.E., Barnes,A.L., Sudhan,D.R., Wittenborn,T.R., Siemann,D.W., Horsman,M.R., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L\<br\>Bioorg Med Chem (2015) 23, 6974-6992. PubMed  Europe PubMed DOI  I
  65. Wang,H., Sang,N., Zhang,C., Raghupathi,R., Tanzi,R.E. and Saunders,A. \<br\>Cathepsin L mediates the degradation of novel APP C-terminal fragments\<br\>Biochemistry (2015) 54, 2806-2816. PubMed  Europe PubMed DOI  I
  66. Yang,N., Wang,P., Wang,W.J., Song,Y.Z. and Liang,Z.Q. \<br\>Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-kappaB signaling pathway\<br\>Acta Pharmacol Sin (2015) 36, 400-410. PubMed  Europe PubMed DOI  I
  67. 2014
  68. Chua,K.C., Pietsch,M., Zhang,X., Hautmann,S., Chan,H.Y., Bruning,J.B., Gutschow,M. and Abell,A.D. \<br\>Macrocyclic protease inhibitors with reduced peptide character\<br\>Angew Chem Int Ed Engl (2014) 53, 7828-7831. PubMed  Europe PubMed DOI  I
  69. Dana,D., De,S., Rathod,P., Davalos,A.R., Novoa,D.A., Paroly,S., Torres,V.M., Afzal,N., Lankalapalli,R.S., Rotenberg,S.A., Chang,E.J., Subramaniam,G. and Kumar,S. \<br\>Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L - a hybrid design approach\<br\>Chem Commun (Camb) (2014) 50, 10875-10878. PubMed  Europe PubMed DOI  I
  70. Elshabrawy,H.A., Fan,J., Haddad,C.S., Ratia,K., Broder,C.C., Caffrey,M. and Prabhakar,B.S. \<br\>Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay\<br\>J Virol (2014) 88, 4353-4365. PubMed  Europe PubMed DOI  I
  71. Miller,B., Friedman,A.J., Choi,H., Hogan,J., McCammon,J.A., Hook,V. and Gerwick,W.H. \<br\>The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L\<br\>J Nat Prod (2014) 77, 92-99. PubMed  Europe PubMed DOI  I
  72. Ramalho,S.D., De Sousa,L.R., Nebo,L., Maganhi,S.H., Caracelli,I., Zukerman-Schpector,J., Lima,M.I., Alves,M.F., da Silva,M.F., Fernandes,J.B. and Vieira,P.C. \<br\>Triterpenoids as novel natural inhibitors of human cathepsin L\<br\>Chem Biodivers (2014) 11, 1354-1363. PubMed  Europe PubMed DOI  I
  73. 2013
  74. Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y. \<br\>Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors\<br\>Bioorg Chem (2013) 51, 24-30. PubMed  Europe PubMed DOI  I
  75. Ehmke,V., Winkler,E., Banner,D.W., Haap,W., Schweizer,W.B., Rottmann,M., Kaiser,M., Freymond,C., Schirmeister,T. and Diederich,F. \<br\>Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L\<br\>ChemMedChem (2013) 8, 967-975. PubMed  Europe PubMed DOI  I
  76. Song,J., Jones,L.M., Chavarria,G.E., Charlton-Sevcik,A.K., Jantz,A., Johansen,A., Bayeh,L., Soeung,V., Snyder,L.K., Lade,S.D., Jr., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks\<br\>Bioorg Med Chem Lett (2013) 23, 2801-2807. PubMed  Europe PubMed DOI  I
  77. Torkar,A., Lenarcic,B., Lah,T., Dive,V. and Devel,L. \<br\>Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors?\<br\>Bioorg Med Chem Lett (2013) 23, 2968-2973. PubMed  Europe PubMed DOI  I
  78. Wang,Y.R., Qin,S., Han,R., Wu,J.C., Liang,Z.Q., Qin,Z.H. and Wang,Y. \<br\>Cathepsin L plays a role in quinolinic acid-induced NF-Kappab activation and excitotoxicity in rat striatal neurons\<br\>PLoS ONE (2013) 8, e75702. PubMed  Europe PubMed DOI  PMC  EPMC  I
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  80. Chavarria,G.E., Horsman,M.R., Arispe,W.M., Kumar,G.D., Chen,S.E., Strecker,T.E., Parker,E.N., Chaplin,D.J., Pinney,K.G. and Trawick,M.L. \<br\>Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L\<br\>Eur J Med Chem (2012) 58, 568-572. PubMed  Europe PubMed DOI  I
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  84. Song,J., Jones,L.M., Kumar,G.D.K., Conner,E.S., Bayeh,L., Chavarria,G.E., Charlton-Sevcik,A.K., Chen,S.E., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L\<br\>ACS Med Chem Lett (2012) 3, 450-453. PubMed  Europe PubMed DOI  I
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  86. Shenoy,R.T. and Sivaraman,J. \<br\>Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors\<br\>J Struct Biol (2011) 173, 14-19. PubMed  Europe PubMed DOI  I
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  89. Frizler,M., Stirnberg,M., Sisay,M.T. and Gutschow,M. \<br\>Development of nitrile-based peptidic inhibitors of cysteine cathepsins\<br\>Curr Top Med Chem (2010) 10, 294-322. PubMed  Europe PubMed DOI  T  I
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  91. Kumar,G.D., Chavarria,G.E., Charlton-Sevcik,A.K., Yoo,G.K., Song,J., Strecker,T.E., Siim,B.G., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L\<br\>Bioorg Med Chem Lett (2010) 20, 6610-6615. PubMed  Europe PubMed DOI  I
  92. Shah,P.P., Wang,T., Kaletsky,R.L., Myers,M.C., Purvis,J.E., Jing,H., Huryn,D.M., Greenbaum,D.C., Smith,A.B., III, Bates,P. and Diamond,S.L. \<br\>A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells\<br\>Mol Pharmacol (2010) 78, 319-324. PubMed  Europe PubMed DOI  I
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  95. Asaad,N., Bethel,P.A., Coulson,M.D., Dawson,J.E., Ford,S.J., Gerhardt,S., Grist,M., Hamlin,G.A., James,M.J., Jones,E.V., Karoutchi,G.I., Kenny,P.W., Morley,A.D., Oldham,K., Rankine,N., Ryan,D., Wells,S.L., Wood,L., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S. \<br\>Dipeptidyl nitrile inhibitors of cathepsin L\<br\>Bioorg Med Chem Lett (2009) 19, 4280-4283. PubMed  Europe PubMed DOI  I
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  113. Yang,M., Zhang,Y., Pan,J., Sun,J., Liu,J., Libby,P., Sukhova,G.K., Doria,A., Katunuma,N., Peroni,O.D., Guerre-Millo,M., Kahn,B.B., Clement,K. and Shi,G.P. \<br\>Cathepsin L activity controls adipogenesis and glucose tolerance\<br\>Nat Cell Biol (2007) 9, 970-977. PubMed  Europe PubMed DOI  K  I
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