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Literature for peptidase C01.032: cathepsin L

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2026
  1. Smith,J.R., Toro,A., Sabater,A., Kovacic,S., Ban,F., Arevalo,A.P., Crispo,M., Gueron,G., Young,R.N. and Cherkasov,A.
    Pharmacokinetics, pathology and efficacy of SARS-CoV-2 main protease inhibitor VPC285785 in a murine model of coronavirus infection
    Sci Rep (2026) 16, 6905-6905. PubMed  Europe PubMed DOI  PMC  EPMC  I
    2. 2025
  2. Juliano,M.A., Persico,M., Severino,B., Tumbarello,G., Okamoto,D., Fernandes,K.R., Trigo,G., Tanaka,A.S., Lacerda,J.T., Tkachuck,O., Corvino,A., Fiorino,F., Scognamiglio,A., Frecentese,F., Santagada,V., Vertuccio,S., Caliendo,G., Juliano,L. and Fattorusso,C.
    1,2,4-Thiadiazolidin-3,5-Diones as Inhibitors of Cysteine Proteases
    Molecules (2025) 30 PubMed  Europe PubMed DOI  PMC  EPMC  I
  3. Kumar,V., Zhu,J., Chenna,B.C., Hoffpauir,Z.A., Rademacher,A., Rogers,A.M., Tseng,C.T., Drelich,A., Farzandh,S., Lamb,A.L. and Meek,T.D.
    Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents
    J Am Chem Soc (2025) PubMed  Europe PubMed DOI  I
  4. Porzberg,M.R.B., Groenewold,G.J.M., Lyoo,H., Jakob,A.K.M.H., Titulaer,W.H.C., Cavina,L., Poelaert,K.C.K., Zwaagstra,M., Dieteren,C.E.J., Lemmers,J.G.H., Hamdani,S.H., van Buuren,B.N.M., Ackerschott,B., Platteeuw,J., Michorius,J., Martina,B.E.E., Feiters,M.C., Girones,D., van Kuppeveld,F.J.M., van Hemert,M.J. and Rutjes,F.P.J.T.
    Peptidomimetic Phenoxymethyl Ketone Warheads as Potent Dual-Mode Inhibitors against SARS-CoV-2 M(pro) and Cathepsin
    J Med Chem (2025) PubMed  Europe PubMed DOI  I
    5. 2024
  5. Ciaglia,T., Vestuto,V., Di Sarno,V., Musella,S., Smaldone,G., Di Matteo,F., Napolitano,V., Miranda,M.R., Pepe,G., Basilicata,M.G., Novi,S., Capolupo,I., Bifulco,G., Campiglia,P., Gomez-Monterrey,I., Snoeck,R., Andrei,G., Manfra,M., Ostacolo,C., Lauro,G. and Bertamino,A.
    Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization
    Eur J Med Chem (2024) 266, 116128-116128. PubMed  Europe PubMed DOI  I
  6. Deng,W., Hu,X., Tian,X., Zhang,Y., Shang,W., Zhang,L. and Shang,L.
    Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L
    J Med Chem (2024) 67, 17124-17143. PubMed  Europe PubMed DOI  I
  7. Falke,S., Lieske,J., Herrmann,A., Loboda,J., Karnicar,K., Gunther,S., Reinke,P.Y.A., Ewert,W., Usenik,A., Lindic,N., Sekirnik,A., Dretnik,K., Tsuge,H., Turk,V., Chapman,H.N., Hinrichs,W., Ebert,G., Turk,D. and Meents,A.
    Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors
    J Med Chem (2024) 67, 7048-7067. PubMed  Europe PubMed DOI  I
  8. Jangra,S., Raghav,N., Wadhwa,D., Kumar,A., Bhattacharyya,S., Kumar,V. and Sheokand,J.
    Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents
    J Biomater Sci Polym Ed (2024) , 1-19. PubMed  Europe PubMed DOI  I
  9. Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X.
    Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19
    Med (2024) 5, 169-171. PubMed  Europe PubMed DOI  I
  10. Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X.
    Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19
    Med (2024) 5, 42-61. PubMed  Europe PubMed DOI  I
  11. Xie,X., Lan,Q., Zhao,J., Zhang,S., Liu,L., Zhang,Y., Xu,W., Shao,M., Peng,J., Xia,S., Zhu,Y., Zhang,K., Zhang,X., Zhang,R., Li,J., Dai,W., Ge,Z., Hu,S., Yu,C., Wang,J., Ma,D., Zheng,M., Yang,H., Xiao,G., Rao,Z., Lu,L., Zhang,L., Bai,F., Zhao,Y., Jiang,S. and Liu,H.
    Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
    Signal Transduct Target Ther (2024) 9, 54-54. PubMed  Europe PubMed DOI  PMC  EPMC  I
  12. Zhou,W., You,B., Zhao,X., Si,S., Li,Y. and Zhang,J.
    Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors
    SLAS Discov (2024) 29, 100153-100153. PubMed  Europe PubMed DOI  I
    13. 2023
  13. Doijen,J., Temmerman,K., Van den Eynde,C., Diels,A., Van den Broeck,N., Van Gool,M., Heo,I., Jaensch,S., Zwaagstra,M., Diosa Toro,M., Chiu,W., De Jonghe,S., Leyssen,P., Bojkova,D., Ciesek,S., Cinatl,J., Verschueren,L., Buyck,C., van Kuppeveld,F., Neyts,J., Van Loock,M. and Van Damme,E.
    Identification of Z-Tyr-Ala-CHN(2), a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2
    Microorganisms (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC  I
  14. Huang,H., Zhang,Y., Xu,X., Liu,Y., Zhao,J., Ma,L., Lei,J., Ge,W., Li,N., Ma,E., Li,Y. and Yuan,L.
    Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells
    Bioorg Med Chem Lett (2023) 80, 129087-129087. PubMed  Europe PubMed DOI  I
  15. Li,Y., Wang,K., Sun,H., Wu,S., Wang,H., Shi,Y., Li,X., Yan,H., Yang,G., Wu,M., Li,Y., Ding,X., Si,S., Jiang,J., Du,Y., Li,Y. and Hong,B.
    Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2
    Antiviral Res (2023) 214, 105606-105606. PubMed  Europe PubMed DOI  PMC  EPMC  I
  16. Tang,T.T., Li,S.M., Pan,B.W., Xiao,J.W., Pang,Y.X., Xie,S.X., Zhou,Y., Yang,J. and Wei,Y.
    Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure-Activity Relationships
    Molecules (2023) 28 PubMed  Europe PubMed DOI  PMC  EPMC  I
  17. Wang,C., Ye,X., Ding,C., Zhou,M., Li,W., Wang,Y., You,Q., Zong,S., Peng,Q., Duanmu,D., Chen,H., Sun,B. and Qiao,J.
    Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry
    J Agric Food Chem (2023) 71, 5535-5546. PubMed  Europe PubMed DOI  PMC  EPMC  I
    18. 2022
  18. Kwon,C.W., Yeo,S. and Chang,P.S.
    Characterization and molecular docking study of cathepsin L inhibitory peptides (SnuCalCpIs) from Calotropis procera R. Br
    Sci Rep (2022) 12, 5825-5825. PubMed  Europe PubMed DOI  PMC  EPMC  I
  19. Meewan,I., Kattoula,J., Kattoula,J.Y., Skinner,D., Fajtova,P., Giardini,M.A., Woodworth,B., McKerrow,J.H., Lage de Siqueira-Neto,J., O'Donoghue,A.J. and Abagyan,R.
    Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L
    Pharmaceuticals (Basel) (2022) 15 PubMed  Europe PubMed DOI  PMC  EPMC  I
  20. Mondal,S., Chen,Y., Lockbaum,G.J., Sen,S., Chaudhuri,S., Reyes,A.C., Lee,J.M., Kaur,A.N., Sultana,N., Cameron,M.D., Shaffer,S.A., Schiffer,C.A., Fitzgerald,K.A. and Thompson,P.R.
    Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2
    J Am Chem Soc (2022) 144, 21035-21045. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  21. Yang,W.L., Li,Q., Sun,J., Huat Tan,S., Tang,Y.H., Zhao,M.M., Li,Y.Y., Cao,X., Zhao,J.C. and Yang,J.K.
    Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy
    Comput Struct Biotechnol J (2022) 20, 2442-2454. PubMed  Europe PubMed DOI  PMC  EPMC  I
  22. Yu,F., Pan,T., Huang,F., Ying,R., Liu,J., Fan,H., Zhang,J., Liu,W., Lin,Y., Yuan,Y., Yang,T., Li,R., Zhang,X., Lv,X., Chen,Q., Liang,A., Zou,F., Liu,B., Hu,F., Tang,X., Li,L., Deng,K., He,X., Zhang,H., Zhang,Y. and Ma,X.
    Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L
    Front Microbiol (2022) 13, 884034-884034. PubMed  Europe PubMed DOI  PMC  EPMC  I
    23. 2021
  23. Breidenbach,J., Lemke,C., Pillaiyar,T., Schakel,L., Al Hamwi,G., Diett,M., Gedschold,R., Geiger,N., Lopez,V., Mirza,S., Namasivayam,V., Schiedel,A.C., Sylvester,K., Thimm,D., Vielmuth,C., Phuong Vu,L., Zyulina,M., Bodem,J., Gutschow,M. and Muller,C.E.
    Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors
    Angew Chem Int Ed Engl (2021) PubMed  Europe PubMed DOI  I
  24. Hu,Y., Ma,C., Szeto,T., Hurst,B., Tarbet,B. and Wang,J.
    Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses
    ACS Infect Dis (2021) 7, 586-597. PubMed  Europe PubMed DOI  PMC  EPMC  I
  25. Li,Y., Ai,X., Zou,C., Liu,Y., Ma,L., Men,J., Liu,D., Sheng,L., Ruan,X., Liu,H., Li,W., Ma,E. and Yuan,L.
    Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cells
    Bioorg Chem (2021) 115, 105256-105256. PubMed  Europe PubMed DOI  I
  26. Mellott,D.M., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D.H., Hsu,J., Zhu,J., Taylor,Z.W., Kocurek,K.I., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Yoon,M.C., Beck,S., Carlin,A.F., Clark,A.E., Beretta,L., Maneval,D., Hook,V., Frueh,F., Hurst,B.L., Wang,H., Raushel,F.M., O'Donoghue,A.J., de Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H.
    A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells
    ACS Chem Biol (2021) 16, 642-650. PubMed  Europe PubMed DOI  PMC  EPMC  I
  27. Munikishore,R., Wang,L.L., Zhang,S., Zhao,Q.S. and Zuo,Z.
    An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94
    Bioorg Chem (2021) 116, 105317-105317. PubMed  Europe PubMed DOI  I
  28. Phan,H.A.T., Giannakoulias,S.G., Barrett,T.M., Liu,C. and Petersson,E.J.
    Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L
    Chem Sci (2021) 12, 10825-10835. PubMed  Europe PubMed DOI  PMC  EPMC  I
    29. 2020
  29. Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R.
    Potential protease inhibitors and their combinations to block SARS-CoV-2
    J Biomol Struct Dyn (2020) , 1-15. PubMed  Europe PubMed DOI  PMC  EPMC  I
  30. Arafet,K., Gonzalez,F.V. and Moliner,V.
    Quantum mechanics/molecular mechanics studies of the mechanism of cysteine proteases inhibition by dipeptidyl nitroalkenes
    Chemistry (2020) 26, 2002-2012. PubMed  Europe PubMed DOI  I
  31. Ashhurst,A.S., Tang,A.H., Fajtova,P., Yoon,M., Aggarwal,A., Stoye,A., Larance,M., Beretta,L., Drelich,A., Skinner,D., Li,L., Meek,T.D., McKerrow,J.H., Hook,V., Tseng,C.K., Turville,S., Gerwick,W.H., O'Donoghue,A.J. and Payne,R.J.
    Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L
    bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  32. Cianni,L., Rocho,F.D.R., Rosini,F., Bonatto,V., Ribeiro,J.F.R., Lameira,J., Leitao,A., Shamim,A. and Montanari,C.A.
    Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases
    Bioorg Chem (2020) 101, 104039-104039. PubMed  Europe PubMed DOI  I
  33. Dana,D. and Pathak,S.K.
    A review of small molecule inhibitors and functional probes of human cathepsin L
    Molecules (2020) 25 PubMed  Europe PubMed DOI  V  I
  34. Mellott,D., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D., Hsu,J.C., Zhu,J., Taylor,Z., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Beck,S., Carlin,A.F., Clark,A.E., Berreta,L., Maneval,D., Frueh,F., Hurst,B.L., Wang,H., Kocurek,K.I., Raushel,F.M., O'Donoghue,A., Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H.
    A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
    bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  35. Ribeiro,J.F.R., Cianni,L., Li,C., Warwick,T.G., De Vita,D., Rosini,F., Dos Reis Rocho,F., Martins,F.C.P., Kenny,P.W., Lameira,J., Leitao,A., Emsley,J. and Montanari,C.A.
    Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor
    Bioorg Med Chem (2020) 28, 115743-115743. PubMed  Europe PubMed DOI  I
  36. Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J.
    Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L
    bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  37. Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J.
    Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L
    Sci Adv (2020) PubMed  Europe PubMed DOI  I
    38. 2019
  38. Boudreau,P.D., Miller,B.W., McCall,L.I., Almaliti,J., Reher,R., Hirata,K., Le,T., Siqueira-Neto,J.L., Hook,V. and Gerwick,W.H.
    Design of gallinamide A analogs as potent inhibitors of the cysteine proteases human cathepsin L and Trypanosoma cruzi cruzain
    J Med Chem (2019) 62, 9026-9044. PubMed  Europe PubMed DOI  I
  39. Dana,D., Garcia,J., Bhuiyan,A.I., Rathod,P., Joo,L., Novoa,D.A., Paroly,S., Fath,K.R., Chang,E.J. and Pathak,S.K.
    Cell penetrable, clickable and tagless activity-based probe of human cathepsin L
    Bioorg Chem (2019) 85, 505-514. PubMed  Europe PubMed DOI  L  I
  40. Shockey,W.A., Kieslich,C.A., Wilder,C.L., Watson,V. and Platt,M.O.
    Dynamic model of protease state and inhibitor trafficking to predict protease activity in breast cancer cells
    Cell Mol Bioeng (2019) 12, 275-288. PubMed  Europe PubMed DOI  PMC  EPMC  I
  41. Weiss-Sadan,T., Itzhak,G., Kaschani,F., Yu,Z., Mahameed,M., Anaki,A., Ben-Nun,Y., Merquiol,E., Tirosh,B., Kessler,B., Kaiser,M. and Blum,G.
    Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation
    Mol Cell Proteomics (2019) 18, 1330-1344. PubMed  Europe PubMed DOI  I
  42. Yuan,L., Liu,J., He,W., Bao,Y., Sheng,L., Zou,C., Hu,B., Ge,W., Liu,Y., Wang,J., Lin,B., Li,Y. and Ma,E.
    Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells
    Bioorg Chem (2019) 84, 239-253. PubMed  Europe PubMed DOI  I
  43. Yuan,L., Zou,C., Ge,W., Liu,Y., Hu,B., Wang,J., Lin,B., Li,Y. and Ma,E.
    A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis
    Bioorg Chem (2019) , 103417-103417. PubMed  Europe PubMed DOI  I
    44. 2018
  44. Huisman,M., Kodanko,J.P., Arora,K., Herroon,M., Alnaed,M., Endicott,J., Podgorski,I. and Kodanko,J.J.
    Affinity-enhanced luminescent Re(I)- and Ru(II)-based inhibitors of the cysteine protease cathepsin L
    Inorg Chem (2018) 57, 7881-7891. PubMed  Europe PubMed DOI  I
    45. 2017
  45. Dos Santos,D.A., Deobald,A.M., Cornelio,V.E., Avila,R.M.D., Cornea,R.C., Bernasconi,G.C.R., Paixao,M.W., Vieira,P.C. and Correa,A.G.
    Asymmetric synthesis and evaluation of epoxy-alpha-acyloxycarboxamides as selective inhibitors of cathepsin L
    Bioorg Med Chem (2017) 25, 4620-4627. PubMed  Europe PubMed DOI  I
  46. Giroud,M., Ivkovic,J., Martignoni,M., Fleuti,M., Trapp,N., Haap,W., Kuglstatter,A., Benz,J., Kuhn,B., Schirmeister,T. and Diederich,F.
    Inhibition of the cysteine protease human cathepsin L by triazine nitriles: amide???heteroarene pi-stacking interactions and chalcogen bonding in the S3 pocket
    ChemMedChem (2017) 12, 257-270. PubMed  Europe PubMed DOI  I
  47. Hashimoto,Y.
    Gelatin zymography using leupeptin for the detection of various cathepsin L forms
    Methods Mol Biol (2017) 1594, 243-254. PubMed  Europe PubMed DOI  L  I
  48. Kikuta,S., Murai,Y. and Tanaka,E.
    Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons
    Neurosci Lett (2017) 636, 120-126. PubMed  Europe PubMed DOI  I
  49. Kuhn,B., Tichy,M., Wang,L., Robinson,S., Martin,R.E., Kuglstatter,A., Benz,J., Giroud,M., Schirmeister,T., Abel,R., Diederich,F. and Hert,J.
    Prospective evaluation of free energy calculations for the prioritization of cathepsin L inhibitors
    J Med Chem (2017) 60, 2485-2497. PubMed  Europe PubMed DOI  I
  50. Li,Y.Y., Fang,J. and Ao,G.Z.
    Cathepsin B and L inhibitors: a patent review (2010 - present)
    Expert Opin Ther Pat (2017) 27, 643-656. PubMed  Europe PubMed DOI  V  I
  51. Parker,E.N., Odutola,S.O., Wang,Y., Strecker,T.E., Mukherjee,R., Shi,Z., Chaplin,D.J., Trawick,M.L. and Pinney,K.G.
    Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L
    Bioorg Med Chem Lett (2017) 27, 1304-1310. PubMed  Europe PubMed DOI  I
    52. 2016
  52. Burton,L.J., Dougan,J., Jones,J., Smith,B.N., Randle,D., Henderson,V. and Odero-Marah,V.A.
    Targeting the nuclear cathepsin L- CCAAT-displacement protein/cut homeobox transcription factor-epithelial mesenchymal transition pathway in prostate and breast cancer cells with Z-FY-CHO inhibitor
    Mol Cell Biol (2016) 37, e00297-16.-e00297-16. PubMed  Europe PubMed DOI  I
  53. Giroud,M., Harder,M., Kuhn,B., Haap,W., Trapp,N., Schweizer,W.B., Schirmeister,T. and Diederich,F.
    Fluorine scan of inhibitors of the cysteine protease human cathepsin L: dipolar and quadrupolar effects in the pi-stacking of fluorinated phenyl rings on peptide amide bonds
    ChemMedChem (2016) 11, 1042-1047. PubMed  Europe PubMed DOI  I
  54. Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J.
    Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones
    RSC Adv (2016) 6, 34588-34599. DOI  I
  55. Sudhan,D.R., Pampo,C., Rice,L. and Siemann,D.W.
    Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model
    Int J Cancer (2016) 138, 2665-2677. PubMed  Europe PubMed DOI  I
  56. Sudhan,D.R., Rabaglino,M.B., Wood,C.E. and Siemann,D.W.
    Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94
    Clin Exp Metastasis (2016) 33, 461-473. PubMed  Europe PubMed DOI  I
  57. Ueki,N., Wang,W., Swenson,C., McNaughton,C., Sampson,N.S. and Hayman,M.J.
    Synthesis and preclinical evaluation of a highly improved anticancer prodrug activated by histone deacetylases and cathepsin L
    Theranostics (2016) 6, 808-816. PubMed  Europe PubMed DOI  PMC  EPMC  I
  58. Zhou,N., Pan,T., Zhang,J., Li,Q., Zhang,X., Bai,C., Huang,F., Peng,T., Zhang,J., Liu,C., Tao,L. and Zhang,H.
    Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)
    J Biol Chem (2016) 291, 9218-9232. PubMed  Europe PubMed DOI  I
    59. 2015
  59. Celis-Barros,C., Saavedra-Rivas,L., Salgado,J.C., Cassels,B.K. and Zapata-Torres,G.
    Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition
    J Comput Aided Mol Des (2015) 29, 37-46. PubMed  Europe PubMed DOI  I
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