A dihydroisorhamnetin that has 2R,3R-configuration.
Identification
(2R,3R)-3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one
(+)-3'-O-methyltaxifolin
(+)-3,4',5,7-tetrahydroxy-3'-methoxyflavanone
(2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
(2R,3R)-3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
(2R,3R)-3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydrochromen-4-one
(2R-trans)-2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
Species
beta vulgaris
NCBI:txid161934 7765684
oryza sativa japonica group
NCBI:txid39947 10.1021/jf403072c
dillenia indica
NCBI:txid4378 10.1039/P19750000612
pulicaria jaubertii
NCBI:txid557693 10.1080/14786419.2015.1055492
Europe PubMed Central results
Flavonoids from the grains of C1/R-S transgenic rice, the transgenic Oryza sativa spp. japonica, and their radical scavenging activities.
Author: Cho JG, Song NY, Nam TG, Shrestha S, Park HJ, Lyu HN, Kim DO, Lee G, Woo YM, Jeong TS, Baek NI.
Abstract: The transgenic rice cultivar of Oryza sativa spp. japonica cv. Hwa-Young, C1/R-S transgenic rice (C1/R-S rice), is a flavonoid-rich cultivar of rice. The grains of C1/R-S rice were extracted with aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H2O, successively. Repeated silica gel, octadecyl silica gel (ODS), and Sephadex LH-20 column chromatographies for the EtOAc and n-BuOH fractions afforded four new flavonoids (compounds 2, 3, 7, and 8) along with four known flavonoids: (+)-3'-O-methyltaxifolin (1), brassicin (4), isorhamnetin-4'-O-β-D-glucosyranoside (5), and 3'-O-methyltaxifolin-5-O-β-D-glucopyranoside (6). The new flavonoids were identified as 3'-O-methyltaxifolin-7-O-β-D-glucopyranoside (2), 3'-O-methyltaxifolin-4'-O-β-D-glucopyranoside (3), isorhamnetin-7-O-β-D-cellobioside (brassicin-4″-O-β-D-glucopyranoside) (7), and brassicin-4'-O-β-D-glucosyranoside (8) from the result of spectroscopic data including nuclear magnetic resonance spectrometry (NMR), mass spectrometry (MS), and infrared spectroscopy (IR). Also, quantitative analysis of major flavonoids (compounds 2, 3, and 8) in C1/R-S rice, O. sativa spp. japonica cv. Hwa-Young (HY), and a hybrid of two cultivar (C1/R-S rice/HY) extracts was performed using HPLC experiment. The isolated flavonoids were evaluated for their radical-scavenging effect on DPPH and ABTS radicals.
DOI: 10.1021/jf403072c
A new monoterpene glucoside and complete assignments of dihydroflavonols of Pulicaria jaubertii: potential cytotoxic and blood pressure lowering activity.
Author: Ragab EA, Raafat M.
Abstract: One new monoterpene glucoside and five dihydroflavonols were isolated for the first time from the aerial parts of Pulicaria jaubertii and identified as p-menthane-2-O-β-D-glucopyranoside [1], dihydroquercetin (taxifolin) [2], 7,3'-di-O-methyltaxifolin [3], 3'-O-methyltaxifolin [4], 7-O-methyltaxifolin (padmatin) [5] and 7-O-methyl-dihydrokampferol (7-O-methylaromadenderin) [6]. The structures of these compounds were unambiguously assigned on the basis of NMR spectroscopic data ((1)H, (13)C, DEPT, HSQC, HMBC) and MS analysis. 2D-NMR methods required revision of assignments of H-6 and H-8 for dihydroflavonol compounds. Possible cytotoxic activity as well as blood pressure (BP) lowering activity were tested. The alcoholic extract showed cytotoxic activity against prostate carcinoma (PC-3), breast carcinoma (MCF-7) and hepatocellular carcinoma (HepG-2) human cell lines with IC50 19.1, 20.0 and 24.1 μg, respectively. The higher dose levels of the alcoholic extract significantly reduced normal BP of rats in a dose-dependent manner.
Phenotypic and Molecular Characteristics of Community-Associated <i>Staphylococcus aureus</i> Infection in Neonates.
Author: Dong Q, Liu Y, Li W, Chen M, Li W, Wang X, Fu J, Ye X.
Abstract: <h4>Background</h4><i>Staphylococcus aureus</i> is an important human pathogen causing a wide variety of diseases ranging from mild skin infections to life-threatening bacteremia. This study aimed to provide insight into the phenotype-genotype characteristics of <i>S. aureus</i> isolated from neonates.<h4>Methods</h4>A hospital-based retrospective study was conducted to recruit neonatal patients with community-associated <i>S. aureus</i> infection. All 92 <i>S. aureus</i> clinical isolates were tested for antimicrobial susceptibility, resistance genes, virulence genes, and multilocus sequence typing.<h4>Results</h4>A total of 92 <i>S. aureus</i> isolates were included in this study, including 29 (31.5%) MRSA isolates. Most <i>S. aureus</i> isolates were susceptible to gentamicin, and most methicillin-resistant <i>S. aureus</i> (MRSA) isolates were susceptible to vancomycin and linezolid. The predominant <i>S. aureus</i> genotypes were CC188 (ST188), CC59 (ST338), CC5 (ST5), CC88 (ST8), and CC6 (ST6), with CC59 (ST338) as the most prevalent MRSA. We observed a significantly corresponding relationship between clonal complexes and resistance patterns (such as CC45/CC59/CC121/CC630 associated with multidrug resistance) or the number of virulence genes (such as CC1/CC5/CC45/CC59/CC88 associated with harboring 5-7 virulence genes, and CC22/CC25/CC121 associated with carrying 8-13 genes). Moreover, both univariate and multivariate analyses indicated that invasive <i>S. aureus</i> isolates were significantly associated with resistance to several classes of antibiotics and carrying specific virulence factors.<h4>Conclusion</h4>Our findings provide insight into phenotype-genotype characteristics for <i>S. aureus</i> isolates so as to provide new ideas for differentiating potential genetic backgrounds and monitoring new epidemiologic trends.
DOI: 10.2147/idr.s284781