A dihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5 and 7 and a methoxy group at position 6. Isolated from Pisonia aculeata, it exhibits antitubercular activity.
Identification
5,7-dihydroxy-6-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
5,7-dihydroxy-6-methoxyflavanone
Species
pisonia aculeata
NCBI:txid363212 21542597
NCBI:txid363212 21542597
Europe PubMed Central results
Insect antifeedant compounds from Nothofagus dombeyi and N. pumilio.
Author: Thoison O, Sévenet T, Niemeyer HM, Russell GB.
Abstract: A bioassay-guided purification of the extracts of Nothofagus dombeyi and N. pumilio leaves yielded several triterpenes and flavonoids including 2-O-acetylmaslinic acid, 3-O-acetyl 20,24,25-trihydroxydammarane, and 3,20,24,25-tetrahydroxydammarane as new natural products. All the isolated compounds were assessed for antifeeding activity against the 5th instar larvae of Ctenopsteustis obliquana. 12-Hydroxyoleanolic lactone and pectolinarigenin from N. dombeyi and dihydrooroxylin A from N. pumilio, showed significant antifeeding activity.
Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.
Author: Li J, Ding Y, Li XC, Ferreira D, Khan S, Smillie T, Khan IA.
Abstract: Two new dihydropyranocoumarins, scuteflorins A (1) and B (2), together with the known compounds decursin (3), chrysin (4), oroxylin A (5), wogonin (6), 5,7-dihydroxy-8,2'-dimethoxyflavone, dihydrochrysin, dihydrooroxylin A, lupenol, scutellaric acid, pomolic acid, ursolic acid, beta-sitosterol, daucosterol, and palmitic acid, were isolated from the aerial parts of Scutellaria lateriflora, commonly used as a dietary supplement. The structures of 1 and 2 were established by means of 1D and 2D NMR spectra as well as HRMS data. The absolute configuration of coumarins 1 and 2 was determined by comparison of experimental and theoretical calculated CD spectra. The cytotoxicity and antioxidant effects of the methanol extract of this plant and some of the constituent flavonoids were evaluated in vitro.
DOI: 10.1021/np900068t
Antitubercular chromones and flavonoids from Pisonia aculeata.
Author: Wu MC, Peng CF, Chen IS, Tsai IL.
Abstract: Three new chromones, pisonins A (1), B (2), and D (4), two new flavonoids, pisonivanone [(2S)-5,7,2'-trihydroxy-8-methylflavanone] (7) and pisonivanol [(2R,3R)-3,7-dihydroxy-5,6-dimethoxyflavanone] (8), one new isoflavonoid, pisonianone (5,7,2'-trihydroxy-6-methoxy-8-methylisoflavone) (9), and five compounds first isolated from nature, namely, pisonins C (3), E (5), and F (6), pisoniamide (10), and pisonolic acid (11), together with 18 known compounds have been isolated from the methanol extract of the combined stem and root of Pisonia aculeata. Among these isolates, 2, 7, 14, 16, and 19 exhibited antitubercular activities (MICs≤50.0 μg/mL) against Mycobacterium tuberculosis H37Rv in vitro.
DOI: 10.1021/np1008575
Lightweight mobile network for real-time violence recognition.
Author: Zhang Y, Li Y, Guo S.
Abstract: Most existing violence recognition methods have complex network structures and high cost of computation and cannot meet the requirements of large-scale deployment. The purpose of this paper is to reduce the complexity of the model to realize the application of violence recognition on mobile intelligent terminals. To solve this problem, we propose MobileNet-TSM, a lightweight network, which uses MobileNet-V2 as main structure. By incorporating temporal shift modules (TSM), which can exchange information between frames, the capability of extracting dynamic characteristics between consecutive frames is strengthened. Extensive experiments are conducted to prove the validity of this method. Our proposed model has only 8.49MB parameters and 175.86MB estimated total size. Compared with the existing methods, this method greatly reduced the model size, at the cost of an accuracy gap of about 3%. The proposed model has achieved accuracy of 97.959%, 97.5% and 87.75% on three public datasets (Crowd Violence, Hockey Fights, and RWF-2000), respectively. Based on this, we also build a real-time violence recognition application on the Android terminal. The source code and trained models are available on https://github.com/1840210289/MobileNet-TSM.git.
Birth weight was associated with maternal exposure to intimate partner violence during pregnancy in southern Ethiopia: A prospective cohort study.
Author: Belay S, Astatkie A, Hinderaker SG.
Abstract: <h4>Introduction</h4>Birth weight is defined as the first weight of the newborn, ideally measured soon after birth. A recent Ethiopian survey estimated that 48% of births took place in health facilities. Data for women exposed to intimate partner violence (IPV) may be lacking in official statistics because these women may prefer to deliver at home, where data from non-institutional births, including reporting of birth weights, are not routinely recorded.<h4>Objective</h4>The aim of this study was to investigate the association between maternal exposure to IPV during pregnancy and birth weight in a community in the Wondo Genet district of southern Ethiopia.<h4>Methods</h4>We carried out a community-based prospective cohort study from February to December 2017. We followed up with 505 pregnant women and their newborns until after delivery. An interview about partner violence was done during pregnancy at home when enrolled. Field assistants who visited the homes measured the birth weight of each baby in grams. Twins and late birth weight measurements were excluded. Factors associated with birth weight were assessed by multiple linear regression.<h4>Results</h4>Birth weight was assessed within 48 h for 477 (94.5%) newborns and between 48 and 72 h for an additional 28 (5.5%). There were 365 (72.3%) institutional deliveries. In an adjusted regression analysis (IPV adjusted for socio-economic status), birth weight was 203 g lower (B -203 95% CI -320 to -87) among newborns of women exposed to IPV than among the unexposed. Birth weight was also lower in girls than in boys, in newborns delivered at home rather than in a health facility, and in babies with a younger gestational age.<h4>Conclusion</h4>Maternal exposure to IPV during pregnancy was associated with lower baby birth weights. Antenatal clinics should consider routinely identifying IPV-exposed women, and identifying babies with lower birth weights at home is an important indicator.