A natural product found in Talaromyces thermophilus.
Identification
(3S)-3-(1H-indol-3-ylmethyl)piperazine-2,5-dione
Species
talaromyces thermophilus
NCBI:txid28565 21967034
Europe PubMed Central results
Isolation of talathermophilins from the thermophilic fungus Talaromyces thermophilus YM3-4.
Author: Guo JP, Tan JL, Wang YL, Wu HY, Zhang CP, Niu XM, Pan WZ, Huang XW, Zhang KQ.
Abstract: Six indole alkaloids with various levels of prenylation were isolated from the thermophilic fungus Talaromyces thermophilus strain YM3-4. Their structures were identified by NMR and MS spectroscopic analyses. Compounds 1 and 2 are new analogues of the key versatile precursor notoamide E. Compound 3 is a novel analogue of preechinulin, and compound 4 was reported as a natural occurring cyclo(glycyltryptophyl) for the first time. The metabolite profile of this thermophilic organism displayed a biosynthetic pathway for talathermophilins.
DOI: 10.1021/np200365z