PDBe < PISA < EMBL-EBI

PISA Interface List.

Session Map (id=227-5K-FN8)

Interfaces in PDB 4uwk crystal.
Space symmetry group: P 21 21 2. Resolution: 2.83 Å

DISCOVERY OF (2S)-8-((3R)-3-METHYLMORPHOLIN-4-YL)-1-(3- METHYL-2-OXO-BUTYL)-2-(TRIFLUOROMETHYL)-3,4-DIHYDRO-2H- PYRIMIDO(1,2-A)PYRIMIDIN-6-ONE: A NOVEL POTENT AND SELECTIVE INHIBITOR OF VPS34 FOR THE TREATMENT OF SOLID TUMORS

Interfaces

##		Structure 1				×	Structure 2						interface area, Å²	ΔⁱG kcal/mol	ΔⁱG P-value	N_HB	N_SB	N_DS	CSS
NN	«»	Range	ⁱN_at	ⁱN_res	Surface Å²	×	Range	Symmetry op-n	Sym.ID	ⁱN_at	ⁱN_res	Surface Å²	interface area, Å²	ΔⁱG kcal/mol	ΔⁱG P-value	N_HB	N_SB	N_DS	CSS
`1`		A	`97`	`27`	`24310`	`◊`	A	-x,-y,z	`2_555`	`96`	`27`	`24310`	`991.7`	`1.4`	`0.720`	`26`	`4`	`0`	`0.000`
`2`		A	`81`	`21`	`24310`	`x`	A	x,y,z-1	`1_554`	`91`	`30`	`24310`	`800.6`	`-4.0`	`0.345`	`7`	`1`	`0`	`0.000`
`3`		A	`56`	`15`	`24310`	`x`	A	x-1/2,-y-1/2,-z-1	`4_444`	`67`	`19`	`24310`	`587.4`	`2.3`	`0.748`	`5`	`4`	`0`	`0.000`
`4`		[UJB]A:1872	`27`	`1`	`588`	`f`	A	x,y,z	`1_555`	`52`	`20`	`24310`	`397.0`	`-6.3`	`0.236`	`1`	`0`	`0`	`0.037`
`5`		[GOL]A:1871	`6`	`1`	`219`	`f`	A	x,y,z	`1_555`	`11`	`5`	`24310`	`83.4`	`-0.5`	`0.508`	`2`	`0`	`0`	`0.008`
`6`		A	`12`	`5`	`24310`	`x`	A	x-1/2,-y-1/2,-z	`4_445`	`10`	`3`	`24310`	`79.9`	`-1.4`	`0.286`	`0`	`0`	`0`	`0.000`
`7`		[SO4]A:1870	`5`	`1`	`186`	`f`	A	x,y,z	`1_555`	`9`	`4`	`24310`	`69.6`	`-9.6`	`0.423`	`1`	`0`	`0`	`0.055`
`8`		[GOL]A:1871	`3`	`1`	`219`	`◊`	A	x,y,z-1	`1_554`	`3`	`1`	`24310`	`27.9`	`0.9`	`0.825`	`1`	`0`	`0`	`0.000`
`9`		A	`3`	`1`	`24310`	`x`	A	-x,-y,z-1	`2_554`	`1`	`1`	`24310`	`23.3`	`0.5`	`0.836`	`1`	`1`	`0`	`0.000`

PDBe PISA v1.52 [20/10/2014]

Protein Data Bank
in Europe

Bringing Structure to Biology

PDBePISA

Protein Data Bank in Europe

Bringing Structure to Biology

PDBePISA

Protein Data Bank
in Europe