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PISA Interface List.

Session Map (id=132-DE-640)

Interfaces in PDB 5tt7 crystal.
Space symmetry group: P 21 21 21. Resolution: 1.77 Å

DISCOVERY OF TAK-659, AN ORALLY AVAILABLE INVESTIGATIONAL INHIBITOR OF SPLEEN TYROSINE KINASE (SYK)

Interfaces

##		Structure 1				×	Structure 2						interface area, Å²	ΔⁱG kcal/mol	ΔⁱG P-value	N_HB	N_SB	N_DS	CSS
NN	«»	Range	ⁱN_at	ⁱN_res	Surface Å²	×	Range	Symmetry op-n	Sym.ID	ⁱN_at	ⁱN_res	Surface Å²	interface area, Å²	ΔⁱG kcal/mol	ΔⁱG P-value	N_HB	N_SB	N_DS	CSS
`1`		A	`73`	`21`	`13894`	`x`	A	-x,y-1/2,-z+1/2	`3_545`	`66`	`21`	`13894`	`589.9`	`-2.5`	`0.462`	`6`	`0`	`0`	`0.000`
`2`		A	`58`	`17`	`13894`	`x`	A	x-1,y,z	`1_455`	`54`	`19`	`13894`	`485.8`	`2.9`	`0.807`	`10`	`4`	`0`	`0.000`
`3`		A	`51`	`12`	`13894`	`x`	A	-x-1/2,-y,z-1/2	`2_454`	`45`	`8`	`13894`	`403.0`	`-2.1`	`0.442`	`4`	`3`	`0`	`0.000`
`4`		[7KF]A:901	`26`	`1`	`553`	`◊`	A	x,y,z	`1_555`	`41`	`19`	`13894`	`382.0`	`3.3`	`0.296`	`6`	`0`	`0`	`0.000`
`5`		A	`27`	`8`	`13894`	`x`	A	-x-1,y-1/2,-z+1/2	`3_445`	`12`	`3`	`13894`	`199.6`	`1.0`	`0.697`	`4`	`1`	`0`	`0.000`
`6`		A	`5`	`2`	`13894`	`x`	A	x-1/2,-y-1/2,-z	`4_445`	`3`	`1`	`13894`	`30.5`	`-1.0`	`0.216`	`0`	`0`	`0`	`0.000`
`7`		A	`1`	`1`	`13894`	`f`	[7KF]A:901	-x,y-1/2,-z+1/2	`3_545`	`1`	`1`	`553`	`3.8`	`0.2`	`0.621`	`0`	`0`	`0`	`0.000`

PDBe PISA v1.52 [20/10/2014]

Protein Data Bank
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