PDBe < PISA < EMBL-EBI

PISA Interface List.

Session Map (id=529-H3-D41)

Interfaces in PDB 5wev crystal.
Space symmetry group: C 1 2 1. Resolution: 1.85 Å

IDENTIFICATION OF AN IMIDAZOPYRIDINE SCAFFOLD TO GENERATE POTENT AND SELECTIVE TYK2 INHIBITORS THAT DEMONSTRATE ACTIVITY IN AN IN VIVO PSORIASIS MODEL

Interfaces

##		Structure 1				×	Structure 2						interface area, Å²	ΔⁱG kcal/mol	ΔⁱG P-value	N_HB	N_SB	N_DS	CSS
NN	«»	Range	ⁱN_at	ⁱN_res	Surface Å²	×	Range	Symmetry op-n	Sym.ID	ⁱN_at	ⁱN_res	Surface Å²	interface area, Å²	ΔⁱG kcal/mol	ΔⁱG P-value	N_HB	N_SB	N_DS	CSS
`1`		A	`117`	`25`	`16172`	`x`	A	-x+1/2,y-1/2,-z-1	`4_544`	`128`	`30`	`16172`	`1212.9`	`-3.3`	`0.336`	`19`	`13`	`0`	`0.000`
`2`		A	`59`	`16`	`16172`	`◊`	A	-x,y,-z-1	`2_554`	`60`	`16`	`16172`	`546.4`	`-9.0`	`0.054`	`2`	`0`	`0`	`0.000`
`3`		A	`51`	`15`	`16172`	`x`	A	x,y,z-1	`1_554`	`45`	`13`	`16172`	`430.3`	`3.6`	`0.808`	`10`	`4`	`0`	`0.000`
`4`		A	`44`	`13`	`16172`	`x`	A	-x+1/2,y-1/2,-z	`4_545`	`55`	`12`	`16172`	`420.3`	`-0.1`	`0.523`	`3`	`0`	`0`	`0.000`
`5`		A	`40`	`11`	`16172`	`◊`	A	-x,y,-z	`2_555`	`38`	`11`	`16172`	`357.8`	`-2.8`	`0.296`	`6`	`0`	`0`	`0.000`
`6`		[9ZS]A:1201	`22`	`1`	`529`	`f`	A	x,y,z	`1_555`	`48`	`21`	`16172`	`321.4`	`-10.8`	`0.250`	`1`	`0`	`0`	`0.100`
`7`		[9ZS]A:1201	`3`	`1`	`529`	`◊`	A	-x,y,-z-1	`2_554`	`4`	`2`	`16172`	`37.8`	`-0.3`	`0.504`	`0`	`0`	`0`	`0.000`

PDBe PISA v1.52 [20/10/2014]

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PDBePISA

Protein Data Bank in Europe

Bringing Structure to Biology

PDBePISA

Protein Data Bank
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