{
  "iri" : "http://purl.obolibrary.org/obo/CHEBI_64187",
  "lang" : "en",
  "description" : [ "A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone." ],
  "synonyms" : [ "2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide", "DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide", "DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide", "Ro 4-4602", "Ro 44602", "benserazida", "benserazide", "benserazidum" ],
  "annotation" : {
    "charge" : [ "0" ],
    "formula" : [ "C10H15N3O5" ],
    "has_dbxref" : [ "CAS:322-35-0", "Drug_Central:314", "KEGG:D03082", "LINCS:LSM-5097", "PMID:12703659", "PMID:22236652", "Patent:BE619015", "Patent:US3178476", "Reaxys:3984490", "Wikipedia:Benserazide" ],
    "has_obo_namespace" : [ "chebi_ontology" ],
    "id" : [ "CHEBI:64187" ],
    "inchi" : [ "InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18)" ],
    "inchikey" : [ "BNQDCRGUHNALGH-UHFFFAOYSA-N" ],
    "mass" : [ "257.24320" ],
    "monoisotopicmass" : [ "257.10117" ],
    "smiles" : [ "NC(CO)C(=O)NNCc1ccc(O)c(O)c1O" ]
  },
  "label" : "benserazide",
  "ontology_name" : "chebi",
  "ontology_prefix" : "CHEBI",
  "ontology_iri" : "http://purl.obolibrary.org/obo/chebi.owl",
  "is_obsolete" : false,
  "term_replaced_by" : null,
  "is_defining_ontology" : true,
  "has_children" : false,
  "is_root" : false,
  "short_form" : "CHEBI_64187",
  "obo_id" : "CHEBI:64187",
  "in_subset" : [ "3_STAR" ],
  "obo_definition_citation" : null,
  "obo_xref" : [ {
    "database" : "CAS",
    "id" : "322-35-0",
    "description" : "ChemIDplus",
    "url" : null
  }, {
    "database" : "Drug_Central",
    "id" : "314",
    "description" : "DrugCentral",
    "url" : "http://drugcentral.org/drugcard/314"
  }, {
    "database" : "KEGG",
    "id" : "D03082",
    "description" : null,
    "url" : "http://www.kegg.jp/entry/D03082"
  }, {
    "database" : "LINCS",
    "id" : "LSM-5097",
    "description" : null,
    "url" : null
  }, {
    "database" : "PMID",
    "id" : "12703659",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/12703659"
  }, {
    "database" : "PMID",
    "id" : "22236652",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/22236652"
  }, {
    "database" : "Patent",
    "id" : "BE619015",
    "description" : null,
    "url" : "https://www.google.com/patents/BE619015"
  }, {
    "database" : "Patent",
    "id" : "US3178476",
    "description" : null,
    "url" : "https://www.google.com/patents/US3178476"
  }, {
    "database" : "Reaxys",
    "id" : "3984490",
    "description" : "Reaxys",
    "url" : null
  }, {
    "database" : "Wikipedia",
    "id" : "Benserazide",
    "description" : null,
    "url" : "http://en.wikipedia.org/wiki/Benserazide"
  } ],
  "obo_synonym" : [ {
    "name" : "2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide",
    "scope" : "hasExactSynonym",
    "type" : "IUPAC NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "IUPAC",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Ro 4-4602",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Ro 44602",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "benserazida",
    "scope" : "hasRelatedSynonym",
    "type" : "INN",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "benserazide",
    "scope" : "hasRelatedSynonym",
    "type" : "INN",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "benserazidum",
    "scope" : "hasRelatedSynonym",
    "type" : "INN",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  } ],
  "is_preferred_root" : false,
  "_links" : {
    "self" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_64187?lang=en"
    },
    "parents" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_64187/parents"
    },
    "ancestors" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_64187/ancestors"
    },
    "hierarchicalParents" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_64187/hierarchicalParents"
    },
    "hierarchicalAncestors" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_64187/hierarchicalAncestors"
    },
    "jstree" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_64187/jstree"
    },
    "graph" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_64187/graph"
    },
    "is_conjugate_base_of" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_64187/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252Fchebi%2523is_conjugate_base_of"
    },
    "has_role" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_64187/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FRO_0000087"
    }
  }
}