{
  "iri" : "http://purl.obolibrary.org/obo/CHEBI_7581",
  "lang" : "en",
  "description" : [ "A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome)." ],
  "synonyms" : [ "7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one", "1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one", "2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one", "7-nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one", "7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one", "Apodorm", "Atempol", "Benzalin", "Calsmin", "Dormicum", "Eatan", "Eunoctin", "Gerson", "Hipnax", "Hipsal", "Ibrovek", "Imeson", "Imesont", "Mogadon", "N-desmethylnimetazepam", "Nelbon", "Nelmat", "Neozepam", "Neuchlonic", "Nitrados", "Paxisyn", "Pelson", "Persopit", "Radedorm", "Relact", "Remnos", "Ro 4-5360", "Ro 5-3059", "Somitran", "Sonebon", "Sonnolin", "Surem", "Trazenin", "Unisomnia", "nitrazepam", "nitrazepamum" ],
  "annotation" : {
    "charge" : [ "0" ],
    "formula" : [ "C15H11N3O3" ],
    "has_dbxref" : [ "CAS:146-22-5", "DrugBank:DB01595", "Drug_Central:1945", "HMDB:HMDB0015534", "KEGG:C07487", "KEGG:D00531", "LINCS:LSM-5681", "PMID:10030438", "PMID:15637997", "PMID:18603831", "PMID:19557123", "PMID:23085494", "PMID:23245766", "PMID:331868", "PMID:578380", "PMID:6143468", "PMID:6926838", "PMID:6988458", "PMID:7037262", "Patent:US3121076", "Reaxys:757185", "Wikipedia:Nitrazepam" ],
    "has_obo_namespace" : [ "chebi_ontology" ],
    "id" : [ "CHEBI:7581" ],
    "inchi" : [ "InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)" ],
    "inchikey" : [ "KJONHKAYOJNZEC-UHFFFAOYSA-N" ],
    "mass" : [ "281.26610" ],
    "monoisotopicmass" : [ "281.08004" ],
    "smiles" : [ "[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3)c2c1" ]
  },
  "label" : "nitrazepam",
  "ontology_name" : "chebi",
  "ontology_prefix" : "CHEBI",
  "ontology_iri" : "http://purl.obolibrary.org/obo/chebi.owl",
  "is_obsolete" : false,
  "term_replaced_by" : null,
  "is_defining_ontology" : true,
  "has_children" : false,
  "is_root" : false,
  "short_form" : "CHEBI_7581",
  "obo_id" : "CHEBI:7581",
  "in_subset" : [ "3_STAR" ],
  "obo_definition_citation" : null,
  "obo_xref" : [ {
    "database" : "CAS",
    "id" : "146-22-5",
    "description" : "KEGG COMPOUND",
    "url" : null
  }, {
    "database" : "CAS",
    "id" : "146-22-5",
    "description" : "ChemIDplus",
    "url" : null
  }, {
    "database" : "CAS",
    "id" : "146-22-5",
    "description" : "NIST Chemistry WebBook",
    "url" : null
  }, {
    "database" : "DrugBank",
    "id" : "DB01595",
    "description" : null,
    "url" : "http://www.drugbank.ca/drugs/DB01595"
  }, {
    "database" : "Drug_Central",
    "id" : "1945",
    "description" : "DrugCentral",
    "url" : "http://drugcentral.org/drugcard/1945"
  }, {
    "database" : "HMDB",
    "id" : "HMDB0015534",
    "description" : null,
    "url" : "http://www.hmdb.ca/metabolites/HMDB0015534"
  }, {
    "database" : "KEGG",
    "id" : "C07487",
    "description" : null,
    "url" : "http://www.kegg.jp/entry/C07487"
  }, {
    "database" : "KEGG",
    "id" : "D00531",
    "description" : null,
    "url" : "http://www.kegg.jp/entry/D00531"
  }, {
    "database" : "LINCS",
    "id" : "LSM-5681",
    "description" : null,
    "url" : null
  }, {
    "database" : "PMID",
    "id" : "10030438",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/10030438"
  }, {
    "database" : "PMID",
    "id" : "15637997",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/15637997"
  }, {
    "database" : "PMID",
    "id" : "18603831",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/18603831"
  }, {
    "database" : "PMID",
    "id" : "19557123",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/19557123"
  }, {
    "database" : "PMID",
    "id" : "23085494",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/23085494"
  }, {
    "database" : "PMID",
    "id" : "23245766",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/23245766"
  }, {
    "database" : "PMID",
    "id" : "331868",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/331868"
  }, {
    "database" : "PMID",
    "id" : "578380",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/578380"
  }, {
    "database" : "PMID",
    "id" : "6143468",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/6143468"
  }, {
    "database" : "PMID",
    "id" : "6926838",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/6926838"
  }, {
    "database" : "PMID",
    "id" : "6988458",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/6988458"
  }, {
    "database" : "PMID",
    "id" : "7037262",
    "description" : "Europe PMC",
    "url" : "http://www.ncbi.nlm.nih.gov/pubmed/7037262"
  }, {
    "database" : "Patent",
    "id" : "US3121076",
    "description" : null,
    "url" : "https://www.google.com/patents/US3121076"
  }, {
    "database" : "Reaxys",
    "id" : "757185",
    "description" : "Reaxys",
    "url" : null
  }, {
    "database" : "Wikipedia",
    "id" : "Nitrazepam",
    "description" : null,
    "url" : "http://en.wikipedia.org/wiki/Nitrazepam"
  } ],
  "obo_synonym" : [ {
    "name" : "7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one",
    "scope" : "hasExactSynonym",
    "type" : "IUPAC NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "IUPAC",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "NIST_Chemistry_WebBook",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "NIST_Chemistry_WebBook",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "7-nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "NIST_Chemistry_WebBook",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "NIST_Chemistry_WebBook",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Apodorm",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Atempol",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Benzalin",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Calsmin",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Dormicum",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Eatan",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Eunoctin",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Gerson",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Hipnax",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Hipsal",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Ibrovek",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Imeson",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Imesont",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Mogadon",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "NIST_Chemistry_WebBook",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "N-desmethylnimetazepam",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "NIST_Chemistry_WebBook",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Nelbon",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Nelmat",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Neozepam",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Neuchlonic",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Nitrados",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Paxisyn",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Pelson",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Persopit",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Radedorm",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Relact",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Remnos",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Ro 4-5360",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Ro 5-3059",
    "scope" : "hasRelatedSynonym",
    "type" : null,
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Somitran",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Sonebon",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Sonnolin",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Surem",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Trazenin",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "Unisomnia",
    "scope" : "hasRelatedSynonym",
    "type" : "BRAND NAME",
    "xrefs" : [ {
      "database" : null,
      "id" : "ChemIDplus",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "nitrazepam",
    "scope" : "hasRelatedSynonym",
    "type" : "INN",
    "xrefs" : [ {
      "database" : null,
      "id" : "WHO_MedNet",
      "description" : null,
      "url" : null
    } ]
  }, {
    "name" : "nitrazepamum",
    "scope" : "hasRelatedSynonym",
    "type" : "INN",
    "xrefs" : [ {
      "database" : null,
      "id" : "WHO_MedNet",
      "description" : null,
      "url" : null
    } ]
  } ],
  "is_preferred_root" : false,
  "_links" : {
    "self" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_7581?lang=en"
    },
    "parents" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_7581/parents"
    },
    "ancestors" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_7581/ancestors"
    },
    "hierarchicalParents" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_7581/hierarchicalParents"
    },
    "hierarchicalAncestors" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_7581/hierarchicalAncestors"
    },
    "jstree" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_7581/jstree"
    },
    "graph" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_7581/graph"
    },
    "has_role" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/chebi/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCHEBI_7581/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FRO_0000087"
    }
  }
}