{
  "iri" : "http://purl.obolibrary.org/obo/NCIT_C2754",
  "lang" : "en",
  "description" : [ "A 9-residued peptide vaccine consisting of amino acids 157 through 165 of the cancer/testis (CT) antigen ESO-1. Modified at position 165 (cysteine to valine) to improve immunogenicity, ESO-1:157-165(165v) peptide administered as a vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for ESO-1, resulting in decreased tumor growth. ESO-1 is expressed in a variety of cancers, including melanoma, breast, bladder, prostate, and hepatocellular cancers.  (NCI04)" ],
  "synonyms" : [ "ESO-1:157-165(165V) Peptide" ],
  "annotation" : {
    "Has_Target" : [ "http://purl.obolibrary.org/obo/NCIT_C39286" ],
    "Legacy Concept Name" : [ "ESO-1_157-165_165v_Peptide" ],
    "NSC Number" : [ "717388" ],
    "Preferred_Name" : [ "ESO-1:157-165(165V) Peptide" ],
    "Semantic_Type" : [ "Amino Acid, Peptide, or Protein", "Pharmacologic Substance" ],
    "UMLS_CUI" : [ "C1512136" ],
    "code" : [ "C2754" ]
  },
  "label" : "ESO-1:157-165(165V) Peptide",
  "ontology_name" : "ncit",
  "ontology_prefix" : "NCIT",
  "ontology_iri" : "http://purl.obolibrary.org/obo/ncit.owl",
  "is_obsolete" : false,
  "term_replaced_by" : null,
  "is_defining_ontology" : true,
  "has_children" : false,
  "is_root" : false,
  "short_form" : "NCIT_C2754",
  "obo_id" : "NCIT:C2754",
  "in_subset" : null,
  "obo_definition_citation" : null,
  "obo_xref" : null,
  "obo_synonym" : [ {
    "name" : "ESO-1:157-165(165V) Peptide",
    "scope" : "hasExactSynonym",
    "type" : null,
    "xrefs" : [ ]
  } ],
  "is_preferred_root" : false,
  "_links" : {
    "self" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754?lang=en"
    },
    "parents" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754/parents"
    },
    "ancestors" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754/ancestors"
    },
    "hierarchicalParents" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754/hierarchicalParents"
    },
    "hierarchicalAncestors" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754/hierarchicalAncestors"
    },
    "jstree" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754/jstree"
    },
    "graph" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754/graph"
    },
    "Chemical_Or_Drug_Has_Physiologic_Effect" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_R125"
    },
    "Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_R72"
    },
    "Chemical_Or_Drug_Has_Mechanism_Of_Action" : {
      "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C2754/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_R124"
    }
  }
}