{ "iri" : "http://purl.obolibrary.org/obo/NCIT_C3174", "lang" : "en", "description" : [ "A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival." ], "synonyms" : [ "BCR-ABL Positive Chronic Myelogenous Leukemia", "CML", "CML - Chronic Myelogenous Leukemia", "Chronic Granulocytic Leukemia", "Chronic Myelocytic Leukemia", "Chronic Myelogenous Leukemia", "Chronic Myelogenous Leukemia (CML)", "Chronic Myelogenous Leukemia, BCR-ABL1 Positive", "Chronic Myelogenous Leukemia, BCR::ABL1 Positive", "Chronic Myelogenous Leukemias", "Chronic Myeloid Leukemia", "Chronic Myeloid Leukemia, BCR-ABL1 Positive", "Chronic Myeloid Leukemia, BCR::ABL1 Positive", "Chronic myelogenous leukemia, BCR-ABL positive", "Hematopoeitic - Chronic Myelocytic Leukemia (CML)", "chronic granulocytic leukemia", "chronic myelogenous leukemia", "chronic myeloid leukemia" ], "annotation" : { "ALT_DEFINITION" : [ "A slowly progressing disease in which too many white blood cells are made in the bone marrow." ], "Contributing_Source" : [ "CPTAC", "CTRP", "Cellosaurus", "GDC" ], "Display_Name" : [ "Chronic Myelogenous Leukemia, BCR-ABL1 Positive" ], "ICD-O-3_Code" : [ "9863/3", "9875/3" ], "Is_Value_For_GDC_Property" : [ "http://purl.obolibrary.org/obo/NCIT_C176985", "http://purl.obolibrary.org/obo/NCIT_C177621" ], "Legacy Concept Name" : [ "Chronic_Myelogenous_Leukemia" ], "Maps_To" : [ "9863/3", "9875/3", "Chronic granulocytic leukemia, NOS", "Chronic myelocytic leukemia, NOS", "Chronic myelogenous leukemia, BCR-ABL positive", "Chronic myelogenous leukemia, BCR/ABL positive", "Chronic myeloid leukaemia [CML], BCR/ABL-positive", "Chronic myeloid leukemia without mention of having achieved remission", "Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission", "Chronic myeloid leukemia, NOS", "Myeloid leukemia, chronic" ], "Neoplastic_Status" : [ "Malignant" ], "Preferred_Name" : [ "Chronic Myeloid Leukemia, BCR-ABL1 Positive" ], "Semantic_Type" : [ "Neoplastic Process" ], "UMLS_CUI" : [ "C0023473" ], "code" : [ "C3174" ] }, "label" : "Chronic Myeloid Leukemia, BCR-ABL1 Positive", "ontology_name" : "ncit", "ontology_prefix" : "NCIT", "ontology_iri" : "http://purl.obolibrary.org/obo/ncit.owl", "is_obsolete" : false, "term_replaced_by" : null, "is_defining_ontology" : true, "has_children" : true, "is_root" : false, "short_form" : "NCIT_C3174", "obo_id" : "NCIT:C3174", "in_subset" : [ "NCIT_C116977", "NCIT_C118168", "NCIT_C126659", "NCIT_C138188", "NCIT_C138190", "NCIT_C156952", "NCIT_C156966", "NCIT_C157711", "NCIT_C158520", "NCIT_C165258", "NCIT_C168655", "NCIT_C168656", "NCIT_C168657", "NCIT_C168658", "NCIT_C168661", "NCIT_C168662", "NCIT_C177537", "NCIT_C192842" ], "obo_definition_citation" : null, "obo_xref" : null, "obo_synonym" : [ { "name" : "BCR-ABL Positive Chronic Myelogenous Leukemia", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "CML", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "CML - Chronic Myelogenous Leukemia", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Granulocytic Leukemia", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Myelocytic Leukemia", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Myelogenous Leukemia", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Myelogenous Leukemia (CML)", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Myelogenous Leukemia, BCR-ABL1 Positive", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Myelogenous Leukemia, BCR::ABL1 Positive", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Myelogenous Leukemias", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Myeloid Leukemia", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Myeloid Leukemia, BCR-ABL1 Positive", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic Myeloid Leukemia, BCR::ABL1 Positive", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Chronic myelogenous leukemia, BCR-ABL positive", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Hematopoeitic - 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