{ "iri" : "http://purl.obolibrary.org/obo/NCIT_C4727", "lang" : "en", "description" : [ "Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. (WHO, 2001)" ], "synonyms" : [ "PTLD", "PTLD, NOS", "Post transplant lymphoproliferative disorder, NOS", "Post-Transplant Lymphoproliferative Disorder", "Post-transplant Lymphoproliferative Disorder", "Post-transplant lymphoproliferative disorder (PTLD)", "post-transplant lymphoproliferative disorder" ], "annotation" : { "ALT_DEFINITION" : [ "A condition in which a group of B-cells grow out of control after an organ transplant in patients with weakened immune systems. This usually happens if the patient has also been infected with Epstein-Barr virus. Post-transplant lymphoproliferative disorder may progress to non-Hodgkin lymphoma.", "Abnormal proliferation of B lymphocytes as a complication of immunosuppression occurring after solid organ or allogenic stem cell transplantation." ], "Contributing_Source" : [ "CTRP", "GDC", "MedDRA", "NICHD", "mCode" ], "Display_Name" : [ "Post-Transplant Lymphoproliferative Disorder" ], "ICD-O-3_Code" : [ "9971/1" ], "Is_Value_For_GDC_Property" : [ "http://purl.obolibrary.org/obo/NCIT_C176985", "http://purl.obolibrary.org/obo/NCIT_C177621" ], "Legacy Concept Name" : [ "Post-Transplant_Lymphoproliferative_Disorder" ], "Maps_To" : [ "9971/1", "PTLD, NOS", "Post transplant lymphoproliferative disorder", "Post transplant lymphoproliferative disorder, NOS", "Post-transplant lymphoproliferative disorder, NOS" ], "Preferred_Name" : [ "Post-Transplant Lymphoproliferative Disorder" ], "Semantic_Type" : [ "Disease or Syndrome" ], "UMLS_CUI" : [ "C0432487" ], "code" : [ "C4727" ] }, "label" : "Post-Transplant Lymphoproliferative Disorder", "ontology_name" : "ncit", "ontology_prefix" : "NCIT", "ontology_iri" : "http://purl.obolibrary.org/obo/ncit.owl", "is_obsolete" : false, "term_replaced_by" : null, "is_defining_ontology" : true, "has_children" : true, "is_root" : false, "short_form" : "NCIT_C4727", "obo_id" : "NCIT:C4727", "in_subset" : [ "NCIT_C116977", "NCIT_C118168", "NCIT_C118464", "NCIT_C157711", "NCIT_C168655", "NCIT_C168656", "NCIT_C168657", "NCIT_C168658", "NCIT_C168661", "NCIT_C168662", "NCIT_C177537", "NCIT_C189762", "NCIT_C193006", "NCIT_C193231", "NCIT_C193248", "NCIT_C193249", "NCIT_C90259" ], "obo_definition_citation" : null, "obo_xref" : null, "obo_synonym" : [ { "name" : "PTLD", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "PTLD, NOS", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Post transplant lymphoproliferative disorder, NOS", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Post-Transplant Lymphoproliferative Disorder", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Post-transplant Lymphoproliferative Disorder", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "Post-transplant lymphoproliferative disorder (PTLD)", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] }, { "name" : "post-transplant lymphoproliferative disorder", "scope" : "hasExactSynonym", "type" : null, "xrefs" : [ ] } ], "is_preferred_root" : false, "_links" : { "self" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727?lang=en" }, "parents" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/parents" }, "ancestors" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/ancestors" }, "hierarchicalParents" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/hierarchicalParents" }, "hierarchicalAncestors" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/hierarchicalAncestors" }, "jstree" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/jstree" }, "children" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/children" }, "descendants" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/descendants" }, "hierarchicalChildren" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/hierarchicalChildren" }, "hierarchicalDescendants" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/hierarchicalDescendants" }, "graph" : { "href" : "https://www.ebi.ac.uk/ols4/api/ontologies/ncit/terms/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C4727/graph" } } }