ilomastat
An N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor
Also appears inslm
Exact Synonyms
(2R)-N(4)-hydroxy-N(1)-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
Related Synonyms
CS 610
galardin
GM 6001
GM-6001
GM6001
ilomastat
class Information
charge
0
formula
C20H28N4O4
has_alternative_id
has_dbxref
- CAS:142880-36-2
- KEGG:D03793
- LINCS:LSM-3143
- PDBeChem:GM6
- PMID:12410973
- PMID:14568001
- PMID:15350544
- PMID:16565079
- PMID:16712832
- PMID:18782669
- PMID:18790756
- PMID:18837084
- PMID:19545667
- PMID:20299089
- PMID:20818082
- PMID:21040999
- PMID:21146503
- PMID:22512086
- PMID:22903888
- PMID:23141517
- PMID:23870824
- PMID:24380772
- PMID:24589605
- PMID:25576979
- PMID:26171681
- PMID:26394037
- PMID:27038494
- PMID:27112177
- PMID:27296149
- PMID:27708133
- PMID:27743382
- PMID:28297575
- PMID:28298987
- PMID:28417261
- Reaxys:7982373
- Wikipedia:Ilomastat
has_obo_namespace
chebi_ontology
inchikey
NITYDPDXAAFEIT-DYVFJYSZSA-N
inchi
InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
in_subset
mass
388.461
monoisotopicmass
388.21106
smiles
C(C(NO)=O)[C@H](C(N[C@H](C(NC)=O)CC=1C=2C(NC1)=CC=CC2)=O)CC(C)C