levesquamide
A polyketide-nonribosomal peptide with an isothiazolinone moiety found in Streptomyces sp. RKND-216. It has a strong selective activity against M. tuberculosis, with no cytotoxicity against mammalian cell lines.
Also appears inslm
Exact Synonyms
(2S)-2-{5-[2-(2-aminophenyl)-1,3-oxazol-4-yl]-7-hydroxy-6-methoxy-3-oxo[1,2]thiazolo[4,5-b]pyridin-2(3H)-yl}-3-hydroxy-N-[(2R)-2-hydroxy-3-{[(2S)-1-hydroxy-4-methylpentan-2-yl]amino}-3-oxopropyl]propanamide
- chemical entity (200,444)
- molecular entity (196,129)
- main group molecular entity (194,229)
- p-block molecular entity (193,541)
- carbon group molecular entity (189,246)
- organic molecular entity (189,106)
- heteroorganic entity (151,906)
- organic heterocyclic compound (58,446)
- heteroarene (10,340)
- monocyclic heteroarene (3,028)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- azole (3,004)
- monocyclic heteroarene (3,028)
- organic heteropolycyclic compound (25,471)
- organonitrogen heterocyclic compound (35,353)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- thiazolopyridine (6)
- azole (3,004)
- organosulfur heterocyclic compound (2,647)
- oxacycle (21,330)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- heteroarene (10,340)
- organochalcogen compound (125,492)
- organooxygen compound (119,501)
- carboxamide (32,463)
- ether (8,663)
- aromatic ether (5,420)
- oxacycle (21,330)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- polyketide (2,500)
- organosulfur compound (9,017)
- organooxygen compound (119,501)
- organonitrogen compound (70,247)
- carboxamide (32,463)
- organic amino compound (21,666)
- aromatic amine (1,923)
- anilines (417)
- aromatic amine (1,923)
- organonitrogen heterocyclic compound (35,353)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- thiazolopyridine (6)
- azole (3,004)
- organic heterocyclic compound (58,446)
- organic amino compound (21,666)
- aromatic amine (1,923)
- anilines (417)
- aromatic amine (1,923)
- organic hydroxy compound (16,480)
- alcohol (5,887)
- primary alcohol (1,056)
- secondary alcohol (2,372)
- alcohol (5,887)
- organic molecule (108,434)
- organic cyclic compound (84,676)
- carbocyclic compound (15,439)
- benzenoid aromatic compound (13,637)
- organic aromatic compound (38,947)
- aromatic amine (1,923)
- anilines (417)
- aromatic ether (5,420)
- benzenoid aromatic compound (13,637)
- heteroarene (10,340)
- monocyclic heteroarene (3,028)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- azole (3,004)
- monocyclic heteroarene (3,028)
- aromatic amine (1,923)
- organic heterocyclic compound (58,446)
- heteroarene (10,340)
- monocyclic heteroarene (3,028)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- azole (3,004)
- monocyclic heteroarene (3,028)
- organic heteropolycyclic compound (25,471)
- organonitrogen heterocyclic compound (35,353)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- thiazolopyridine (6)
- azole (3,004)
- organosulfur heterocyclic compound (2,647)
- oxacycle (21,330)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- heteroarene (10,340)
- carbocyclic compound (15,439)
- organic cyclic compound (84,676)
- heteroorganic entity (151,906)
- organic molecular entity (189,106)
- chalcogen molecular entity (138,750)
- organochalcogen compound (125,492)
- organooxygen compound (119,501)
- carboxamide (32,463)
- ether (8,663)
- aromatic ether (5,420)
- oxacycle (21,330)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- polyketide (2,500)
- organosulfur compound (9,017)
- organooxygen compound (119,501)
- oxygen molecular entity (132,386)
- hydroxides (27,698)
- organic hydroxy compound (16,480)
- alcohol (5,887)
- primary alcohol (1,056)
- secondary alcohol (2,372)
- alcohol (5,887)
- organic hydroxy compound (16,480)
- organooxygen compound (119,501)
- carboxamide (32,463)
- ether (8,663)
- aromatic ether (5,420)
- oxacycle (21,330)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- polyketide (2,500)
- hydroxides (27,698)
- sulfur molecular entity (11,305)
- organochalcogen compound (125,492)
- pnictogen molecular entity (88,874)
- nitrogen molecular entity (79,787)
- amide (39,309)
- primary amide (37,379)
- carboxamide (32,463)
- primary amide (37,379)
- organonitrogen compound (70,247)
- carboxamide (32,463)
- organic amino compound (21,666)
- aromatic amine (1,923)
- anilines (417)
- aromatic amine (1,923)
- organonitrogen heterocyclic compound (35,353)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- thiazolopyridine (6)
- azole (3,004)
- amide (39,309)
- nitrogen molecular entity (79,787)
- carbon group molecular entity (189,246)
- s-block molecular entity (30,789)
- hydrogen molecular entity (30,008)
- hydroxides (27,698)
- organic hydroxy compound (16,480)
- alcohol (5,887)
- primary alcohol (1,056)
- secondary alcohol (2,372)
- alcohol (5,887)
- organic hydroxy compound (16,480)
- hydroxides (27,698)
- hydrogen molecular entity (30,008)
- p-block molecular entity (193,541)
- polyatomic entity (140,025)
- heteroatomic molecular entity (60,413)
- hydroxides (27,698)
- organic hydroxy compound (16,480)
- alcohol (5,887)
- primary alcohol (1,056)
- secondary alcohol (2,372)
- alcohol (5,887)
- organic hydroxy compound (16,480)
- hydroxides (27,698)
- molecule (108,973)
- cyclic compound (85,378)
- aromatic compound (38,998)
- organic aromatic compound (38,947)
- aromatic amine (1,923)
- anilines (417)
- aromatic ether (5,420)
- benzenoid aromatic compound (13,637)
- heteroarene (10,340)
- monocyclic heteroarene (3,028)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- azole (3,004)
- monocyclic heteroarene (3,028)
- aromatic amine (1,923)
- organic aromatic compound (38,947)
- bicyclic compound (14,239)
- heterobicyclic compound (11,908)
- heterocyclic compound (58,598)
- heterobicyclic compound (11,908)
- heteropolycyclic compound (25,474)
- organic heterocyclic compound (58,446)
- heteroarene (10,340)
- monocyclic heteroarene (3,028)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- azole (3,004)
- monocyclic heteroarene (3,028)
- organic heteropolycyclic compound (25,471)
- organonitrogen heterocyclic compound (35,353)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- thiazolopyridine (6)
- azole (3,004)
- organosulfur heterocyclic compound (2,647)
- oxacycle (21,330)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- heteroarene (10,340)
- homocyclic compound (15,446)
- carbocyclic compound (15,439)
- benzenoid aromatic compound (13,637)
- carbocyclic compound (15,439)
- organic cyclic compound (84,676)
- carbocyclic compound (15,439)
- benzenoid aromatic compound (13,637)
- organic aromatic compound (38,947)
- aromatic amine (1,923)
- anilines (417)
- aromatic ether (5,420)
- benzenoid aromatic compound (13,637)
- heteroarene (10,340)
- monocyclic heteroarene (3,028)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- azole (3,004)
- monocyclic heteroarene (3,028)
- aromatic amine (1,923)
- organic heterocyclic compound (58,446)
- heteroarene (10,340)
- monocyclic heteroarene (3,028)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- azole (3,004)
- monocyclic heteroarene (3,028)
- organic heteropolycyclic compound (25,471)
- organonitrogen heterocyclic compound (35,353)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- thiazolopyridine (6)
- azole (3,004)
- organosulfur heterocyclic compound (2,647)
- oxacycle (21,330)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- heteroarene (10,340)
- carbocyclic compound (15,439)
- polycyclic compound (35,878)
- heteropolycyclic compound (25,474)
- aromatic compound (38,998)
- organic molecule (108,434)
- organic cyclic compound (84,676)
- carbocyclic compound (15,439)
- benzenoid aromatic compound (13,637)
- organic aromatic compound (38,947)
- aromatic amine (1,923)
- anilines (417)
- aromatic ether (5,420)
- benzenoid aromatic compound (13,637)
- heteroarene (10,340)
- monocyclic heteroarene (3,028)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- azole (3,004)
- monocyclic heteroarene (3,028)
- aromatic amine (1,923)
- organic heterocyclic compound (58,446)
- heteroarene (10,340)
- monocyclic heteroarene (3,028)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- azole (3,004)
- monocyclic heteroarene (3,028)
- organic heteropolycyclic compound (25,471)
- organonitrogen heterocyclic compound (35,353)
- azole (3,004)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- thiazolopyridine (6)
- azole (3,004)
- organosulfur heterocyclic compound (2,647)
- oxacycle (21,330)
- oxazole (324)
- 1,3-oxazoles (160)
- oxazole (324)
- heteroarene (10,340)
- carbocyclic compound (15,439)
- organic cyclic compound (84,676)
- cyclic compound (85,378)
- heteroatomic molecular entity (60,413)
- main group molecular entity (194,229)
- molecular entity (196,129)
class Information
charge
0
formula
C28H34N6O9S
has_dbxref
has_obo_namespace
chebi_ontology
inchi
InChI=1S/C28H34N6O9S/c1-13(2)8-14(10-35)31-26(40)19(37)9-30-25(39)18(11-36)34-28(41)21-24(44-34)22(38)23(42-3)20(33-21)17-12-43-27(32-17)15-6-4-5-7-16(15)29/h4-7,12-14,18-19,35-37H,8-11,29H2,1-3H3,(H,30,39)(H,31,40)(H,33,38)/t14-,18-,19+/m0/s1
inchikey
DZVHAUSOBYTBDX-ZOCIIQOWSA-N
in_subset
mass
630.670
monoisotopicmass
630.21080
smiles
COC1=C(O)C2=C(N=C1C1=COC(=N1)C1=CC=CC=C1N)C(=O)N(S2)[C@@H](CO)C(=O)NC[C@@H](O)C(=O)N[C@H](CO)CC(C)C