PJ34
A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.
Also appears inslm
Exact Synonyms
2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
Related Synonyms
2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
2-(dimethylaminoacetylamino)-5,6-dihydrophenanthridine-6-one
N(2),N(2)-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide
N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide
N-(5,6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide
PJ 34
PJ-34
class Information
charge
0
formula
C17H17N3O2
has_alternative_id
has_dbxref
- CAS:344458-19-1
- Chemspider:4692
- DrugBank:DB08348
- LINCS:LSM-4937
- PDBeChem:P34
- PMID:11179503
- PMID:11845877
- PMID:15458385
- PMID:16107839
- PMID:17612561
- PMID:18276581
- PMID:18575783
- PMID:18695907
- PMID:19354255
- PMID:19890834
- PMID:21190076
- PMID:21623955
- PMID:22297980
- PMID:22561282
- PMID:22995423
- PMID:23011206
- PMID:23995751
- PMID:24564608
- PMID:24900770
- PMID:25286857
- PMID:25446913
- PMID:25635049
- PMID:25934569
- PMID:26497583
- PMID:27002155
- PMID:27427773
- PMID:28001384
- PMID:28791810
- PMID:29317476
- PMID:29651748
- PMID:30139380
- PMID:30665718
- PMID:30683694
- PMID:31133874
- PMID:31276434
- PMID:31679124
- PMID:31692907
- PMID:32082490
- PMID:32478624
- PMID:32575437
- PMID:32911782
- PMID:33368686
- PMID:33484702
- PMID:33770364
has_obo_namespace
chebi_ontology
inchi
InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)
inchikey
UYJZZVDLGDDTCL-UHFFFAOYSA-N
in_subset
mass
295.342
monoisotopicmass
295.13208
smiles
CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1
class Relations
Subclass of
- secondary carboxamide
- tertiary amino compound
- phenanthridines
- has rolerosomeantiatherosclerotic agent
- has rolerosomeantineoplastic agent
- has rolerosomeangiogenesis inhibitor
- has rolerosomeEC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor
- has rolerosomeneuroprotective agent
- has rolerosomeanti-inflammatory agent
- has rolerosomeapoptosis inducer
- has rolerosomecardioprotective agent
- is conjugate base ofsomePJ34(1+)
Related from
is conjugate acid of