nabumetone
A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Related Synonyms
4-(6-Methoxy-2-naphthalenyl)-2-butanone
4-(6-Methoxy-2-naphthyl)-2-butanone
nabumetona
nabumetone
nabumetonum
Relafen
class Information
charge
0
formula
C15H16O2
has_dbxref
- CAS:42924-53-8
- DrugBank:DB00461
- Drug_Central:1863
- HMDB:HMDB0014604
- KEGG:D00425
- LINCS:LSM-3453
- PDBeChem:NBO
- PMID:21532165
- PMID:21650014
- PMID:21674107
- PMID:21898684
- PMID:22028826
- PMID:22298755
- PMID:22381180
- PMID:22605805
- PMID:22977877
- PMID:23020786
- PMID:23129452
- PMID:23132511
- PMID:23225308
- PMID:23584048
- PMID:23781476
- PMID:23781467
- PMID:23806470
- PMID:24074034
- PMID:24083957
- Reaxys:2103472
- Wikipedia:Nabumetone
has_obo_namespace
chebi_ontology
inchi
InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3
inchikey
BLXXJMDCKKHMKV-UHFFFAOYSA-N
in_subset
mass
228.28630
monoisotopicmass
228.11503
smiles
COc1ccc2cc(CCC(C)=O)ccc2c1