trametinib
A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Exact Synonyms
N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
Related Synonyms
GSK 1120212
JTP 74057
trametinib
trametinibum
class Information
charge
0
formula
C26H23FIN5O4
has_dbxref
- CAS:871700-17-3
- Chemspider:9881833
- DrugBank:DB08911
- Drug_Central:4802
- KEGG:D10175
- LINCS:LSM-1143
- Patent:WO2011047238
- Patent:WO2005121142
- Patent:WO2011038082
- Patent:WO2011038085
- PMCID:PMC7715110
- PMID:21523318
- PMID:22245957
- PMID:23035153
- PMID:23237773
- PMID:23248257
- PMID:23290787
- PMID:23432625
- PMID:23438367
- PMID:23441129
- PMID:23533766
- PMID:23583440
- PMID:23587417
- PMID:23649971
- PMID:23658559
- PMID:23709751
- PMID:23807941
- PMID:23844038
- PMID:23846731
- PMID:23893461
- PMID:23971497
- PMID:23977666
- PMID:24055054
- PMID:26119340
- PMID:33922284
- PMID:34034619
- PMID:34145930
- PMID:34156985
- PMID:34282746
- PMID:34355652
- PMID:34413035
- PMID:34421360
- PMID:34484797
- PMID:34516041
- PMID:34590600
- PMID:34592184
- Reaxys:12497153
- Wikipedia:Trametinib
has_obo_namespace
chebi_ontology
inchi
InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
inchikey
LIRYPHYGHXZJBZ-UHFFFAOYSA-N
in_subset
mass
615.39480
monoisotopicmass
615.07788
smiles
CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
class Relations
Subclass of
Related from
has part