huperzine A
A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Exact Synonyms
(5R,9R,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
Related Synonyms
(-)-huperazine A
(-)-selagine
(5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
Hup A
HupA
huperzine-A
hupzine A
kimpukan A
selagine
class Information
charge
0
formula
C15H18N2O
has_dbxref
- AGR:IND606941294
- CAS:102518-79-6
- Chemspider:16736021
- DrugBank:DB04864
- HMDB:HMDB0242654
- KNApSAcK:C00028361
- PMID:12895686
- PMID:23306162
- PMID:24129696
- PMID:24190328
- PMID:24299147
- PMID:24332448
- PMID:24639880
- PMID:31305343
- PMID:31922239
- PMID:31990212
- PMID:32052235
- PMID:32576772
- PMID:32708929
- PMID:32729341
- PMID:32869005
- PMID:32970179
- PMID:32970952
- PMID:33252842
- PMID:33278032
- PMID:33504676
- PMID:33567664
- PMID:33675928
- PMID:33708959
- PMID:33851462
- PMID:33891962
- PMID:33930191
- PMID:34072855
- PMID:34198639
- PMID:34306441
- PMID:34363318
- PMID:34368579
- PMID:34419561
- Reaxys:3592896
- Wikipedia:Huperzine_A
has_obo_namespace
chebi_ontology
inchi
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
inchikey
ZRJBHWIHUMBLCN-YQEJDHNASA-N
in_subset
mass
242.31620
monoisotopicmass
242.14191
smiles
C\C=C1/[C@@H]2Cc3[nH]c(=O)ccc3[C@@]1(N)CC(C)=C2
class Relations
Subclass of
Related from
is conjugate acid of