trametinib dimethyl sulfoxideImported
An addition compound obtained by combining equimolar amounts of trametinib and dimethyl sulfoxide. Used for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Defined bychebi
Also appears inslm
Exact Synonyms
N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide--(methylsulfinyl)methane (1/1)
Related Synonyms
GSK1120212
GSK1120212B
JTP 74057
Mekinist
Trametinib DMSO
class Information
charge
0
definition source
- https://www.drugbank.ca/drugs/DB08911
- PMID: 26868298
formula
- C26H23FIN5O4.C2H6OS
- C28H29FIN5O5S
has_dbxref
has_obo_namespace
chebi_ontology
imported from
inchi
InChI=1S/C26H23FIN5O4.C2H6OS/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34;1-4(2)3/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);1-2H3
inchikey
OQUFJVRYDFIQBW-UHFFFAOYSA-N
mass
693.52800
monoisotopicmass
693.09181
smiles
CS(C)=O.CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
class Relations
Subclass of
- addition compoundchebi
- has partbfosomedimethyl sulfoxidechebi
- has partbfosometrametinibchebi
- chemical inhibits proteinsomedual specificity mitogen-activated protein kinase kinase 2 (human)pr
- chemical inhibits proteinsomedual specificity mitogen-activated protein kinase kinase 1 (human)pr
- chemical has protein target as antagonistsomedual specificity mitogen-activated protein kinase kinase 2 (human)pr
- chemical has protein target as antagonistsomedual specificity mitogen-activated protein kinase kinase 1 (human)pr
- chemical inhibits in vitro replication of virussomeMiddle East respiratory syndrome-related coronavirusncbitaxon
- has rolerosomeantineoplastic agentchebi
- has rolerosomeEC 2.7.11.24 (mitogen-activated protein kinase) inhibitorchebi