trametinibImported
A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Defined bychebi
Exact Synonyms
N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
Related Synonyms
GSK 1120212
JTP 74057
trametinib
trametinibum
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- aromatic aminechebi (26)
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- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
- organic heteropolycyclic compoundchebi (168)
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- trametinibchebi
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- trametinibchebi
- pyridopyrimidinechebi (1)
- organic heteropolycyclic compoundchebi (168)
- organic heterobicyclic compoundchebi (97)
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- trametinibchebi
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- trametinibchebi
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- organic heterobicyclic compoundchebi (97)
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- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
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- pyridopyrimidinechebi (1)
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- organic aromatic compoundchebi (257)
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- trametinibchebi
- aromatic aminechebi (26)
- organic heterocyclic compoundchebi (357)
- organic heterobicyclic compoundchebi (97)
- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
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- trametinibchebi
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- organic heterobicyclic compoundchebi (97)
- heterobicyclic compoundchebi (98)
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- heterobicyclic compoundchebi (98)
- organic heterobicyclic compoundchebi (97)
- pyridopyrimidinechebi (1)
- trametinibchebi
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- organic heterobicyclic compoundchebi (97)
- heteropolycyclic compoundchebi (170)
- organic heteropolycyclic compoundchebi (168)
- organic heterobicyclic compoundchebi (97)
- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
- organic heterobicyclic compoundchebi (97)
- organic heteropolycyclic compoundchebi (168)
- organic heterocyclic compoundchebi (357)
- organic heterobicyclic compoundchebi (97)
- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
- organic heteropolycyclic compoundchebi (168)
- organic heterobicyclic compoundchebi (97)
- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
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- heterobicyclic compoundchebi (98)
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- carbocyclic compoundchebi (97)
- cyclopropaneschebi (1)
- trametinibchebi
- cyclopropaneschebi (1)
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- organic cyclic compoundchebi (530)
- carbocyclic compoundchebi (97)
- cyclopropaneschebi (1)
- trametinibchebi
- cyclopropaneschebi (1)
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- aromatic aminechebi (26)
- trametinibchebi
- aromatic aminechebi (26)
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- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
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- organic heterobicyclic compoundchebi (97)
- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
- organic heterobicyclic compoundchebi (97)
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- organic heteropolycyclic compoundchebi (168)
- organic heterobicyclic compoundchebi (97)
- pyridopyrimidinechebi (1)
- trametinibchebi
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- trametinibchebi
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- carbocyclic compoundchebi (97)
- cyclopropaneschebi (1)
- trametinibchebi
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- organic aromatic compoundchebi (257)
- aromatic aminechebi (26)
- trametinibchebi
- aromatic aminechebi (26)
- organic heterocyclic compoundchebi (357)
- organic heterobicyclic compoundchebi (97)
- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
- organic heteropolycyclic compoundchebi (168)
- organic heterobicyclic compoundchebi (97)
- pyridopyrimidinechebi (1)
- trametinibchebi
- pyridopyrimidinechebi (1)
- organic heterobicyclic compoundchebi (97)
- organic heterobicyclic compoundchebi (97)
- carbocyclic compoundchebi (97)
- organic cyclic compoundchebi (530)
- cyclic compoundchebi (551)
- cyclic compoundchebi (551)
- main group molecular entitychebi (8,351)
- molecular entitychebi (8,519)
- chemical entitychebi (8,786)
- material entitybfo (12,891)
- independent continuantbfo (12,904)
- continuantbfo (14,429)
class Information
charge
0
formula
C26H23FIN5O4
has_dbxref
- CAS:871700-17-3
- Chemspider:9881833
- DrugBank:DB08911
- Drug_Central:4802
- KEGG:D10175
- LINCS:LSM-1143
- Patent:WO2011038085
- Patent:WO2005121142
- Patent:WO2011038082
- Patent:WO2011047238
- PMCID:PMC7715110
- PMID:21523318
- PMID:22245957
- PMID:23035153
- PMID:23237773
- PMID:23248257
- PMID:23290787
- PMID:23432625
- PMID:23438367
- PMID:23441129
- PMID:23533766
- PMID:23583440
- PMID:23587417
- PMID:23649971
- PMID:23658559
- PMID:23709751
- PMID:23807941
- PMID:23844038
- PMID:23846731
- PMID:23893461
- PMID:23971497
- PMID:23977666
- PMID:24055054
- PMID:26119340
- PMID:33922284
- PMID:34034619
- PMID:34145930
- PMID:34156985
- PMID:34282746
- PMID:34355652
- PMID:34413035
- PMID:34421360
- PMID:34484797
- PMID:34516041
- PMID:34590600
- PMID:34592184
- Reaxys:12497153
- Wikipedia:Trametinib
has_obo_namespace
chebi_ontology
imported from
inchi
InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
inchikey
LIRYPHYGHXZJBZ-UHFFFAOYSA-N
mass
615.39480
monoisotopicmass
615.07788
smiles
CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
class Relations
Subclass of
- acetamideschebi
- aromatic aminechebi
- ring assemblychebi
- organoiodine compoundchebi
- organofluorine compoundchebi
- pyridopyrimidinechebi
- cyclopropaneschebi
- has rolerosomeanticoronaviral agentchebi
- has rolerosomegeroprotectorchebi
- has rolerosomeantineoplastic agentchebi
- has rolerosomeEC 2.7.11.24 (mitogen-activated protein kinase) inhibitorchebi
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