selinexorImported
A member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1Z)-3-oxo-3-[2-(pyrazin-2-yl)hydrazinyl]prop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is a prescription medicine approved for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma.
Defined bychebi
Also appears inslm
Exact Synonyms
(2Z)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(pyrazin-2-yl)prop-2-enehydrazide
Related Synonyms
(2Z)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1- yl}-N'-(pyrazin-2-yl)prop-2-enehydrazide
KPT 330
KPT-330
selinexorum
selinexor
Xpovio
class Information
charge
0
formula
C17H11F6N7O
has_dbxref
- DrugBank:DB11942
- HMDB:HMDB0258217
- KEGG:D11222
- PMID:23373539
- PMID:27893412
- PMID:28314790
- PMID:28810913
- PMID:28852098
- PMID:29707241
- PMID:30064906
- PMID:30115935
- PMID:30996012
- PMID:32598257
- PMID:33403670
- PMID:33507295
- PMID:33601919
- PMID:34488662
- PMID:34669417
- PMID:34741230
- PMID:35355406
- PMID:35477814
- PMID:35667526
- PMID:35941226
- PMID:36180918
- PMID:36200270
- PMID:36622814
- PMID:36731340
- PMID:36827679
- PMID:36847599
- PMID:37016732
- PMID:37046649
- PMID:37047788
- PMID:37079389
- PMID:37094850
- PMID:37126200
- PMID:37175668
- PMID:37184196
- PMID:37191210
- PMID:37346402
- PMID:37595020
- PMID:37715291
- PMID:37760508
- PMID:37945593
- PMID:38105606
- PMID:38186637
- PMID:38454813
- Wikipedia:Selinexor
has_obo_namespace
chebi_ontology
has_RxCUI
2178390
inchi
InChI=1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1-
inchikey
DEVSOMFAQLZNKR-RJRFIUFISA-N
in_subset
mass
443.313
monoisotopicmass
443.09293
smiles
FC(F)(F)C1=CC(=CC(=C1)C1=NN(\C=C/C(=O)NNC2=NC=CN=C2)C=N1)C(F)(F)F