A macrolide that is pristinamycin IIA in which the double bond between positions 26 and 26a of the pyrroline ring has been reduced and position 26R carries a [2-(diethylamino)ethyl]sulfonyl group. It is a semi-synthetic streptogramin antibiotic and often used as a mixture with quinupristin for the treatment of vancomycin-resistant Enterococcus faecium.
class Information
0
C34H50N4O9S
- CAS:112362-50-2
- DrugBank:DB01764
- Drug_Central:778
- HMDB:HMDB0015566
- KEGG:C08033
- KEGG:D00853
- PDBeChem:DOL
- PMID:11985218
- PMID:12771141
- PMID:1328138
- PMID:15059283
- PMID:17563376
- PMID:18056275
- PMID:19409762
- PMID:21453475
- PMID:23044949
- PMID:23924572
- PMID:24827721
- PMID:24957822
- PMID:25218154
- PMID:25566405
- PMID:27158605
- PMID:27528592
- PMID:27689100
- PMID:27769188
- PMID:29478197
- PMID:30169641
- PMID:32321574
- PMID:32812867
- PMID:7843184
- PMID:9653958
- Wikipedia:Dalfopristin
chebi_ontology
229369
InChI=1S/C34H50N4O9S/c1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b10-9+,12-11+,23-18+/t24-,25-,28-,31-,32-/m1/s1
SUYRLXYYZQTJHF-VMBLUXKRSA-N
690.850
690.32985
[H][C@]12[C@@H](CCN1C(=O)C1=COC(CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@@H](C)[C@H](OC2=O)C(C)C)=N1)S(=O)(=O)CCN(CC)CC
class Relations
- secondary carboxamidechebi
- tertiary carboxamidechebi
- macrolide antibioticchebi
- secondary alcoholchebi
- sulfonechebi
- cyclic ketonechebi
- 1,3-oxazoleschebi
- tertiary amino compoundchebi
- enamidechebi
- has rolerosomeantibacterial drugchebi
- has rolerosomeprotein synthesis inhibitorchebi
- has functional parentsomepristinamycin IIAchebi