OntologiesefoclassesEFO:0000519   
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glioblastoma multiforme
http://www.ebi.ac.uk/efo/EFO_0000519

The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)

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Exact Synonyms
GBM (glioblastoma)
GBM
glioblastoma (disease)
glioblastoma multiforme (disease)
glioblastoma multiforme
glioblastoma
grade IV adult astrocytic tumor
grade IV astrocytic neoplasm
grade IV astrocytic tumor
grade IV astrocytic tumour
grade IV astrocytoma
primary glioblastoma multiforme
spongioblastoma multiforme
WHO grade IV glioma
Related Synonyms
giant cell glioblastoma (histologic variant)
gliosarcoma (histologic variant)
Narrow Synonyms
grade IV adult astrocytic tumor
grade IV adult astrocytic tumour
class Information
class Relations