hydroxymethylglutaryl-CoA reductase (NADPH) activity
Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH.
Related Synonyms
hydroxymethylglutaryl-CoA reductase activity
Broad Synonyms
3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
HMG-CoA reductase activity
class Information
has_alternative_id
has_dbxref
- EC:1.1.1.34
- KEGG_REACTION:R02082
- MetaCyc:1.1.1.34-RXN
- Reactome:R-HSA-191352
- RHEA:15989
has_obo_namespace
molecular_function
term tracker item
class Relations
Subclass of
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- has participantrosomehydronchebi
- has participantrosome(R)-mevalonatechebi
- has participantrosome(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)chebi
- has participantrosomecoenzyme A(4-)chebi
- has participantrosomeNADPH(4-)chebi
- has participantrosomeNADP(3-)chebi