long-chain fatty acid-CoA ligase activity
Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see short-chain fatty acidchebi, medium-chain fatty acidchebi, long-chain fatty acidchebi and very long-chain fatty acidchebi). Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
Exact Synonyms
long-chain acyl-CoA synthetase activity
long-chain-fatty-acid-CoA ligase activity
long-chain-fatty-acyl-CoA synthetase activity
Related Synonyms
acyl-CoA ligase activity
acyl-CoA synthetase activity
fatty acid thiokinase (long-chain) activity
LCFA synthetase activity
lignoceroyl-CoA synthase activity
long chain fatty acyl-CoA synthetase activity
long-chain acyl CoA synthetase activity
long-chain acyl-coenzyme A synthetase activity
long-chain fatty acid activation
long-chain fatty acyl coenzyme A synthetase activity
thiokinase
Narrow Synonyms
pristanoyl-CoA synthetase
stearoyl-CoA synthetase
Broad Synonyms
acyl-activating enzyme activity
class Information
has_alternative_id
has_dbxref
- EC:6.2.1.3
- MetaCyc:PWY-5143
- MetaCyc:RXN-7904
- Reactome:R-HSA-192137
- Reactome:R-HSA-193727
- Reactome:R-HSA-193743
- Reactome:R-HSA-5696004
- Reactome:R-HSA-159425
- Reactome:R-HSA-548843
- Reactome:R-HSA-193407
- Reactome:R-HSA-201035
- Reactome:R-HSA-2046098
- Reactome:R-HSA-193401
- Reactome:R-HSA-193766
- Reactome:R-HSA-9734535
- Reactome:R-HSA-193711
- Reactome:R-HSA-193424
- Reactome:R-HSA-2046085
- RHEA:15421
has_obo_namespace
molecular_function
class Relations
Subclass of
- fatty acid-CoA ligase activity
- part ofrosomelong-chain fatty acid metabolic process
- has participantrosomeATP(4-)chebi
- has participantrosomediphosphate(3-)chebi
- has participantrosomeadenosine 5'-monophosphate(2-)chebi
- has participantrosomecoenzyme A(4-)chebi
- has participantrosomelong-chain fatty acid anionchebi
- has participantrosomelong-chain fatty acyl-CoA(4-)chebi