guanyl-nucleotide exchange factor activity
Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Exact Synonyms
GDP-dissociation stimulator activity
GDS
GEF
guanyl-nucleotide release factor activity
guanyl-nucleotide releasing factor
Rho guanine nucleotide exchange factor
RhoGEF
Narrow Synonyms
ARF guanyl-nucleotide exchange factor activity
cAMP-dependent guanyl-nucleotide exchange factor activity
GNRP
Rab guanyl-nucleotide exchange factor activity
Rac guanyl-nucleotide exchange factor activity
Ral guanyl-nucleotide exchange factor activity
Ran guanyl-nucleotide exchange factor activity
Rap guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
Sar guanyl-nucleotide exchange factor activity
class Information
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has_dbxref
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class Relations
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negatively regulates
positively regulates